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Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

Niemann-Pick disease type C (NPC) is associated with mutations in NPC1 and NPC2, whose gene products are key players in the endosomal/lysosomal egress of low-density lipoprotein-derived cholesterol. NPC1 is also the intracellular receptor for Ebola virus (EBOV). Here, we present a 4.4 Å structure of...

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Detalles Bibliográficos
Autores principales:	Gong, Xin, Qian, Hongwu, Zhou, Xinhui, Wu, Jianping, Wan, Tao, Cao, Pingping, Huang, Weiyun, Zhao, Xin, Wang, Xudong, Wang, Peiyi, Shi, Yi, Gao, George F., Zhou, Qiang, Yan, Nieng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111323/ https://www.ncbi.nlm.nih.gov/pubmed/27238017 http://dx.doi.org/10.1016/j.cell.2016.05.022

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