Cargando…

Structure of the Respiratory Syncytial Virus Polymerase Complex

Numerous interventions are in clinical development for respiratory syncytial virus (RSV) infection, including small molecules that target viral transcription and replication. These processes are catalyzed by a complex comprising the RNA-dependent RNA polymerase (L) and the tetrameric phosphoprotein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gilman, Morgan S.A., Liu, Cheng, Fung, Amy, Behera, Ishani, Jordan, Paul, Rigaux, Peter, Ysebaert, Nina, Tcherniuk, Sergey, Sourimant, Julien, Eléouët, Jean-François, Sutto-Ortiz, Priscila, Decroly, Etienne, Roymans, Dirk, Jin, Zhinan, McLellan, Jason S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111336/ https://www.ncbi.nlm.nih.gov/pubmed/31495574 http://dx.doi.org/10.1016/j.cell.2019.08.014

Ejemplares similares

The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation
por: Sutto-Ortiz, Priscila, et al.
Publicado: (2021)

Biochemistry of the Respiratory Syncytial Virus L Protein Embedding RNA Polymerase and Capping Activities
por: Sutto-Ortiz, Priscila, et al.
Publicado: (2023)

Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor
por: Yu, Xiaodi, et al.
Publicado: (2023)

Visualizing the replication of respiratory syncytial virus in cells and in living mice
por: Rameix-Welti, Marie-Anne, et al.
Publicado: (2014)

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor
por: Roymans, Dirk, et al.
Publicado: (2017)

Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase
por: Ahmed-Belkacem, Rostom, et al.
Publicado: (2020)

Respiratory syncytial virus entry and how to block it
por: Battles, Michael B., et al.
Publicado: (2019)

Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase
por: Sourimant, Julien, et al.
Publicado: (2022)

Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex
por: Sourimant, Julien, et al.
Publicado: (2016)

The Insertion of Fluorescent Proteins in a Variable Region of Respiratory Syncytial Virus L Polymerase Results in Fluorescent and Functional Enzymes But with Reduced Activities
por: Fix, Jenna, et al.
Publicado: (2011)

Viral evolution identifies a regulatory interface between paramyxovirus polymerase complex and nucleocapsid that controls replication dynamics
por: Sourimant, Julien, et al.
Publicado: (2020)

Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity
por: Cox, Robert M., et al.
Publicado: (2021)

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
por: Rossey, Iebe, et al.
Publicado: (2017)

Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
por: Rossey, Iebe, et al.
Publicado: (2017)

Structural landscape of the respiratory syncytial virus nucleocapsids
por: Gonnin, Lorène, et al.
Publicado: (2023)

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate
por: Deval, Jerome, et al.
Publicado: (2015)

Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers
por: Rutten, Lucy, et al.
Publicado: (2020)

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain
por: Potisopon, Supanee, et al.
Publicado: (2014)

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain
por: Potisopon, Supanee, et al.
Publicado: (2016)

Genital warts and inflammatory bowel diseases: Danish real‐world evidence to assess patient‐relevant outcomes
por: McLellan, Paul, et al.
Publicado: (2022)

Perianal fistulizing Crohn's disease and overall risk of cancer: No red flag
por: McLellan, Paul, et al.
Publicado: (2023)

Cryo-EM structure of the respiratory syncytial virus RNA polymerase
por: Cao, Dongdong, et al.
Publicado: (2020)

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies
por: Jones, Harrison G., et al.
Publicado: (2018)

Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand RNA viruses
por: Cressey, Tessa N., et al.
Publicado: (2022)

Analysis of Template Variations on RNA Synthesis by Respiratory Syncytial Virus Polymerase
por: Cao, Dongdong, et al.
Publicado: (2022)

Effect of Season and High Ambient Temperature on Activity Levels and Patterns of Grizzly Bears (Ursus arctos)
por: McLellan, Michelle L., et al.
Publicado: (2015)

Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro
por: Galloux, Marie, et al.
Publicado: (2020)

Importance of RNA length for in vitro encapsidation by the nucleoprotein of human respiratory syncytial virus
por: Gonnin, Lorène, et al.
Publicado: (2022)

Conventional and unconventional mechanisms for capping viral mRNA
por: Decroly, Etienne, et al.
Publicado: (2011)

The Respiratory Syncytial Virus Polymerase Has Multiple RNA Synthesis Activities at the Promoter
por: Noton, Sarah L., et al.
Publicado: (2012)

RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V
por: Braun, Molly R., et al.
Publicado: (2017)

Sub-Nucleocapsid Nanoparticles: A Nasal Vaccine against Respiratory Syncytial Virus
por: Roux, Xavier, et al.
Publicado: (2008)

A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading
por: Gaillard, Vanessa, et al.
Publicado: (2017)

The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid
por: Bakker, Saskia E., et al.
Publicado: (2013)

Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus
por: Rincheval, Vincent, et al.
Publicado: (2017)

4′-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication
por: Sourimant, Julien, et al.
Publicado: (2021)

A bovine respiratory syncytial virus model with high clinical expression in calves with specific passive immunity
por: Blodörn, Krister, et al.
Publicado: (2015)

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity
por: Essalmani, Rachid, et al.
Publicado: (2022)

Progress and pitfalls of a year of drug repurposing screens against COVID-19()
por: Sourimant, Julien, et al.
Publicado: (2021)

The young Hegelians and Karl Marx /
por: McLellan, David
Publicado: (1969)

Cannot write session to /tmp/vufind_sessions/sess_19smg21cls7psv8fps0sbp9dmv