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Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease

OBJECTIVE: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stre...

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Autores principales: Barbé-Tuana, Florencia M., Parisi, Mariana M., Panizzutti, Bruna S., Fries, Gabriel R., Grun, Lucas K., Guma, Fátima T., Kapczinski, Flávio, Berk, Michael, Gama, Clarissa S., Rosa, Adriane R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Psiquiatria 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111356/
https://www.ncbi.nlm.nih.gov/pubmed/27798713
http://dx.doi.org/10.1590/1516-4446-2016-1910
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author Barbé-Tuana, Florencia M.
Parisi, Mariana M.
Panizzutti, Bruna S.
Fries, Gabriel R.
Grun, Lucas K.
Guma, Fátima T.
Kapczinski, Flávio
Berk, Michael
Gama, Clarissa S.
Rosa, Adriane R.
author_facet Barbé-Tuana, Florencia M.
Parisi, Mariana M.
Panizzutti, Bruna S.
Fries, Gabriel R.
Grun, Lucas K.
Guma, Fátima T.
Kapczinski, Flávio
Berk, Michael
Gama, Clarissa S.
Rosa, Adriane R.
author_sort Barbé-Tuana, Florencia M.
collection PubMed
description OBJECTIVE: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. METHODS: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. RESULTS: Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively). The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle. CONCLUSION: This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD.
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spelling pubmed-71113562020-04-02 Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease Barbé-Tuana, Florencia M. Parisi, Mariana M. Panizzutti, Bruna S. Fries, Gabriel R. Grun, Lucas K. Guma, Fátima T. Kapczinski, Flávio Berk, Michael Gama, Clarissa S. Rosa, Adriane R. Braz J Psychiatry Original Article OBJECTIVE: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. METHODS: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. RESULTS: Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively). The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle. CONCLUSION: This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD. Associação Brasileira de Psiquiatria 2016-10-17 /pmc/articles/PMC7111356/ /pubmed/27798713 http://dx.doi.org/10.1590/1516-4446-2016-1910 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Barbé-Tuana, Florencia M.
Parisi, Mariana M.
Panizzutti, Bruna S.
Fries, Gabriel R.
Grun, Lucas K.
Guma, Fátima T.
Kapczinski, Flávio
Berk, Michael
Gama, Clarissa S.
Rosa, Adriane R.
Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
title Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
title_full Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
title_fullStr Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
title_full_unstemmed Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
title_short Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
title_sort shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111356/
https://www.ncbi.nlm.nih.gov/pubmed/27798713
http://dx.doi.org/10.1590/1516-4446-2016-1910
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