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Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls

OBJECTIVE: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship betwee...

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Detalles Bibliográficos
Autores principales:	Matsuzaka, Camila T., Christofolini, Denise, Ota, Vanessa K., Gadelha, Ary, Berberian, Arthur A., Noto, Cristiano, Mazzotti, Diego R., Spindola, Leticia M., Moretti, Patricia N., Smith, Marilia A.C., Melaragno, Maria I., Belangero, Sintia I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Associação Brasileira de Psiquiatria 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111404/ https://www.ncbi.nlm.nih.gov/pubmed/28273278 http://dx.doi.org/10.1590/1516-4446-2016-1987

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