Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases

A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialod...

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Detalles Bibliográficos
Autores principales: Stanley, Mathew, Mayr, Juliane, Huber, Wolfgang, Vlasak, Reinhard, Streicher, Hansjörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111470/
https://www.ncbi.nlm.nih.gov/pubmed/21524502
http://dx.doi.org/10.1016/j.ejmech.2011.04.008
Descripción
Sumario:A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialodacryoadenitis virus was found, a 9-O-methyl derivative displayed inhibitory activity against recombinant sialate-9-O-acetylesterase from influenza C virus.

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