Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases

A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialod...

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Detalles Bibliográficos
Autores principales: Stanley, Mathew, Mayr, Juliane, Huber, Wolfgang, Vlasak, Reinhard, Streicher, Hansjörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111470/
https://www.ncbi.nlm.nih.gov/pubmed/21524502
http://dx.doi.org/10.1016/j.ejmech.2011.04.008
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author Stanley, Mathew
Mayr, Juliane
Huber, Wolfgang
Vlasak, Reinhard
Streicher, Hansjörg
author_facet Stanley, Mathew
Mayr, Juliane
Huber, Wolfgang
Vlasak, Reinhard
Streicher, Hansjörg
author_sort Stanley, Mathew
collection PubMed
description A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialodacryoadenitis virus was found, a 9-O-methyl derivative displayed inhibitory activity against recombinant sialate-9-O-acetylesterase from influenza C virus.
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spelling pubmed-71114702020-04-02 Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases Stanley, Mathew Mayr, Juliane Huber, Wolfgang Vlasak, Reinhard Streicher, Hansjörg Eur J Med Chem Original Article A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialodacryoadenitis virus was found, a 9-O-methyl derivative displayed inhibitory activity against recombinant sialate-9-O-acetylesterase from influenza C virus. Elsevier Masson SAS. 2011-07 2011-04-08 /pmc/articles/PMC7111470/ /pubmed/21524502 http://dx.doi.org/10.1016/j.ejmech.2011.04.008 Text en Copyright © 2011 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Stanley, Mathew
Mayr, Juliane
Huber, Wolfgang
Vlasak, Reinhard
Streicher, Hansjörg
Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases
title Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases
title_full Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases
title_fullStr Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases
title_full_unstemmed Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases
title_short Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases
title_sort synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-o-acetylesterases
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111470/
https://www.ncbi.nlm.nih.gov/pubmed/21524502
http://dx.doi.org/10.1016/j.ejmech.2011.04.008
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