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Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma

Alternative polyadenylation (APA) is a gene regulatory process that dictates mRNA 3′-UTR length, resulting in changes in mRNA stability and localization. APA is frequently disrupted in cancer and promotes tumorigenesis through altered expression of oncogenes and tumor suppressors. Pan-cancer analyse...

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Detalles Bibliográficos
Autores principales:	Venkat, Swati, Tisdale, Arwen A., Schwarz, Johann R., Alahmari, Abdulrahman A., Maurer, H. Carlo, Olive, Kenneth P., Eng, Kevin H., Feigin, Michael E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111527/ https://www.ncbi.nlm.nih.gov/pubmed/32029502 http://dx.doi.org/10.1101/gr.257550.119

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