Dual threshold optimization and network inference reveal convergent evidence from TF binding locations and TF perturbation responses

A high-confidence map of the direct, functional targets of each transcription factor (TF) requires convergent evidence from independent sources. Two significant sources of evidence are TF binding locations and the transcriptional responses to direct TF perturbations. Systematic data sets of both typ...

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Detalles Bibliográficos
Autores principales: Kang, Yiming, Patel, Nikhil R., Shively, Christian, Recio, Pamela Samantha, Chen, Xuhua, Wranik, Bernd J., Kim, Griffin, McIsaac, R. Scott, Mitra, Robi, Brent, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111528/
https://www.ncbi.nlm.nih.gov/pubmed/32060051
http://dx.doi.org/10.1101/gr.259655.119

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