A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by cathepsin L

The Nipah virus fusion (F) protein is proteolytically processed to F(1) + F(2) subunits. We demonstrate here that cathepsin L is involved in this important maturation event. Cathepsin inhibitors ablated cleavage of Nipah F. Proteolytic processing of Nipah F and fusion activity was dramatically reduc...

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Detalles Bibliográficos
Autores principales: Pager, Cara Theresia, Craft, Willie Warren, Patch, Jared, Dutch, Rebecca Ellis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111743/
https://www.ncbi.nlm.nih.gov/pubmed/16460775
http://dx.doi.org/10.1016/j.virol.2006.01.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111743/
https://www.ncbi.nlm.nih.gov/pubmed/16460775
http://dx.doi.org/10.1016/j.virol.2006.01.007

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