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A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by cathepsin L
The Nipah virus fusion (F) protein is proteolytically processed to F(1) + F(2) subunits. We demonstrate here that cathepsin L is involved in this important maturation event. Cathepsin inhibitors ablated cleavage of Nipah F. Proteolytic processing of Nipah F and fusion activity was dramatically reduc...
Autores principales: | Pager, Cara Theresia, Craft, Willie Warren, Patch, Jared, Dutch, Rebecca Ellis |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111743/ https://www.ncbi.nlm.nih.gov/pubmed/16460775 http://dx.doi.org/10.1016/j.virol.2006.01.007 |
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