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Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo

Aminopeptidase N, or CD13, is a receptor for serologically related coronaviruses of humans, pigs, and cats. A mouse line transgenic for the receptor of human coronavirus-229E (HCoV-229E) was created using human APN (hAPN) cDNA driven by a hAPN promoter. hAPN-transgenic mice expressed hAPN mRNA in th...

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Detalles Bibliográficos
Autores principales: Wentworth, David E., Tresnan, D.B., Turner, B.C., Lerman, I.R., Bullis, B., Hemmila, E.M., Levis, R., Shapiro, L.H., Holmes, Kathryn V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111747/
https://www.ncbi.nlm.nih.gov/pubmed/15840518
http://dx.doi.org/10.1016/j.virol.2005.02.023