Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides

Starting from a library of 2-l-α-amino acyl (E)-acrylonitriles, different short 2-cyano and 2-amido aziridinyl peptides, potential protease inhibitors, were obtained under parallel solution-phase conditions. The transformations include careful selection of conditions for aziridine deprotection and c...

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Detalles Bibliográficos
Autores principales: Fioravanti, Stefania, Massari, Davide, Morreale, Alberto, Pellacani, Lucio, Tardella, Paolo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111778/
https://www.ncbi.nlm.nih.gov/pubmed/32287417
http://dx.doi.org/10.1016/j.tet.2008.01.098
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author Fioravanti, Stefania
Massari, Davide
Morreale, Alberto
Pellacani, Lucio
Tardella, Paolo A.
author_facet Fioravanti, Stefania
Massari, Davide
Morreale, Alberto
Pellacani, Lucio
Tardella, Paolo A.
author_sort Fioravanti, Stefania
collection PubMed
description Starting from a library of 2-l-α-amino acyl (E)-acrylonitriles, different short 2-cyano and 2-amido aziridinyl peptides, potential protease inhibitors, were obtained under parallel solution-phase conditions. The transformations include careful selection of conditions for aziridine deprotection and cyano group partial hydrolysis.
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spelling pubmed-71117782020-04-02 Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides Fioravanti, Stefania Massari, Davide Morreale, Alberto Pellacani, Lucio Tardella, Paolo A. Tetrahedron Article Starting from a library of 2-l-α-amino acyl (E)-acrylonitriles, different short 2-cyano and 2-amido aziridinyl peptides, potential protease inhibitors, were obtained under parallel solution-phase conditions. The transformations include careful selection of conditions for aziridine deprotection and cyano group partial hydrolysis. Elsevier Ltd. 2008-03-31 2008-01-31 /pmc/articles/PMC7111778/ /pubmed/32287417 http://dx.doi.org/10.1016/j.tet.2008.01.098 Text en Copyright © 2008 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Fioravanti, Stefania
Massari, Davide
Morreale, Alberto
Pellacani, Lucio
Tardella, Paolo A.
Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides
title Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides
title_full Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides
title_fullStr Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides
title_full_unstemmed Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides
title_short Solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides
title_sort solution-phase synthesis of 2-cyano and 2-amido aziridinyl peptides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111778/
https://www.ncbi.nlm.nih.gov/pubmed/32287417
http://dx.doi.org/10.1016/j.tet.2008.01.098
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