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IL-15-independent antiviral function of primary and memory CD8(+) T cells
Memory CD8(+) T cells are comprised of CD122(hi) IL-15-dependent and CD122(lo) IL-15-independent subsets. Induction and retention of IL-15-independent memory CD8(+) T cells was assessed in IL-15(−/−) and wild-type (wt) mice immunized with recombinant vaccinia virus (rVV) or Sindbis virus (rSIN) vect...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111818/ https://www.ncbi.nlm.nih.gov/pubmed/15629776 http://dx.doi.org/10.1016/j.virol.2004.10.035 |
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author | Zuo, Jun Stohlman, Stephen A. Bergmann, Cornelia C. |
author_facet | Zuo, Jun Stohlman, Stephen A. Bergmann, Cornelia C. |
author_sort | Zuo, Jun |
collection | PubMed |
description | Memory CD8(+) T cells are comprised of CD122(hi) IL-15-dependent and CD122(lo) IL-15-independent subsets. Induction and retention of IL-15-independent memory CD8(+) T cells was assessed in IL-15(−/−) and wild-type (wt) mice immunized with recombinant vaccinia virus (rVV) or Sindbis virus (rSIN) vectors expressing the identical foreign epitope. Both vectors induced epitope-specific CD8(+) T cell expansion and function, independent of IL-15. Similar kinetics of rVV clearance confirmed effective CD8(+) T cell function in IL-15(−/−) mice. CD44(hi) CD122(hi) CD8(+) T cells, mainly of the CD62L(−/lo) phenotype, increased more dramatically and declined more rapidly in IL-15(−/−) mice, independent of the vector. Rapid IL-15-independent memory CD8(+) T cell expansion following challenge of immune mice compensated for the limited memory CD8(+) populations in IL-15(−/−) mice. However, despite expansion and expression of potent effector function, viral clearance was delayed in the absence of IL-15, coinciding with a rapid loss in cytolytic function. |
format | Online Article Text |
id | pubmed-7111818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71118182020-04-02 IL-15-independent antiviral function of primary and memory CD8(+) T cells Zuo, Jun Stohlman, Stephen A. Bergmann, Cornelia C. Virology Article Memory CD8(+) T cells are comprised of CD122(hi) IL-15-dependent and CD122(lo) IL-15-independent subsets. Induction and retention of IL-15-independent memory CD8(+) T cells was assessed in IL-15(−/−) and wild-type (wt) mice immunized with recombinant vaccinia virus (rVV) or Sindbis virus (rSIN) vectors expressing the identical foreign epitope. Both vectors induced epitope-specific CD8(+) T cell expansion and function, independent of IL-15. Similar kinetics of rVV clearance confirmed effective CD8(+) T cell function in IL-15(−/−) mice. CD44(hi) CD122(hi) CD8(+) T cells, mainly of the CD62L(−/lo) phenotype, increased more dramatically and declined more rapidly in IL-15(−/−) mice, independent of the vector. Rapid IL-15-independent memory CD8(+) T cell expansion following challenge of immune mice compensated for the limited memory CD8(+) populations in IL-15(−/−) mice. However, despite expansion and expression of potent effector function, viral clearance was delayed in the absence of IL-15, coinciding with a rapid loss in cytolytic function. Elsevier Inc. 2005-01-20 2004-11-20 /pmc/articles/PMC7111818/ /pubmed/15629776 http://dx.doi.org/10.1016/j.virol.2004.10.035 Text en Copyright © 2004 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Zuo, Jun Stohlman, Stephen A. Bergmann, Cornelia C. IL-15-independent antiviral function of primary and memory CD8(+) T cells |
title | IL-15-independent antiviral function of primary and memory CD8(+) T cells |
title_full | IL-15-independent antiviral function of primary and memory CD8(+) T cells |
title_fullStr | IL-15-independent antiviral function of primary and memory CD8(+) T cells |
title_full_unstemmed | IL-15-independent antiviral function of primary and memory CD8(+) T cells |
title_short | IL-15-independent antiviral function of primary and memory CD8(+) T cells |
title_sort | il-15-independent antiviral function of primary and memory cd8(+) t cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111818/ https://www.ncbi.nlm.nih.gov/pubmed/15629776 http://dx.doi.org/10.1016/j.virol.2004.10.035 |
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