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IL-15-independent antiviral function of primary and memory CD8(+) T cells

Memory CD8(+) T cells are comprised of CD122(hi) IL-15-dependent and CD122(lo) IL-15-independent subsets. Induction and retention of IL-15-independent memory CD8(+) T cells was assessed in IL-15(−/−) and wild-type (wt) mice immunized with recombinant vaccinia virus (rVV) or Sindbis virus (rSIN) vect...

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Detalles Bibliográficos
Autores principales: Zuo, Jun, Stohlman, Stephen A., Bergmann, Cornelia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111818/
https://www.ncbi.nlm.nih.gov/pubmed/15629776
http://dx.doi.org/10.1016/j.virol.2004.10.035
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author Zuo, Jun
Stohlman, Stephen A.
Bergmann, Cornelia C.
author_facet Zuo, Jun
Stohlman, Stephen A.
Bergmann, Cornelia C.
author_sort Zuo, Jun
collection PubMed
description Memory CD8(+) T cells are comprised of CD122(hi) IL-15-dependent and CD122(lo) IL-15-independent subsets. Induction and retention of IL-15-independent memory CD8(+) T cells was assessed in IL-15(−/−) and wild-type (wt) mice immunized with recombinant vaccinia virus (rVV) or Sindbis virus (rSIN) vectors expressing the identical foreign epitope. Both vectors induced epitope-specific CD8(+) T cell expansion and function, independent of IL-15. Similar kinetics of rVV clearance confirmed effective CD8(+) T cell function in IL-15(−/−) mice. CD44(hi) CD122(hi) CD8(+) T cells, mainly of the CD62L(−/lo) phenotype, increased more dramatically and declined more rapidly in IL-15(−/−) mice, independent of the vector. Rapid IL-15-independent memory CD8(+) T cell expansion following challenge of immune mice compensated for the limited memory CD8(+) populations in IL-15(−/−) mice. However, despite expansion and expression of potent effector function, viral clearance was delayed in the absence of IL-15, coinciding with a rapid loss in cytolytic function.
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spelling pubmed-71118182020-04-02 IL-15-independent antiviral function of primary and memory CD8(+) T cells Zuo, Jun Stohlman, Stephen A. Bergmann, Cornelia C. Virology Article Memory CD8(+) T cells are comprised of CD122(hi) IL-15-dependent and CD122(lo) IL-15-independent subsets. Induction and retention of IL-15-independent memory CD8(+) T cells was assessed in IL-15(−/−) and wild-type (wt) mice immunized with recombinant vaccinia virus (rVV) or Sindbis virus (rSIN) vectors expressing the identical foreign epitope. Both vectors induced epitope-specific CD8(+) T cell expansion and function, independent of IL-15. Similar kinetics of rVV clearance confirmed effective CD8(+) T cell function in IL-15(−/−) mice. CD44(hi) CD122(hi) CD8(+) T cells, mainly of the CD62L(−/lo) phenotype, increased more dramatically and declined more rapidly in IL-15(−/−) mice, independent of the vector. Rapid IL-15-independent memory CD8(+) T cell expansion following challenge of immune mice compensated for the limited memory CD8(+) populations in IL-15(−/−) mice. However, despite expansion and expression of potent effector function, viral clearance was delayed in the absence of IL-15, coinciding with a rapid loss in cytolytic function. Elsevier Inc. 2005-01-20 2004-11-20 /pmc/articles/PMC7111818/ /pubmed/15629776 http://dx.doi.org/10.1016/j.virol.2004.10.035 Text en Copyright © 2004 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zuo, Jun
Stohlman, Stephen A.
Bergmann, Cornelia C.
IL-15-independent antiviral function of primary and memory CD8(+) T cells
title IL-15-independent antiviral function of primary and memory CD8(+) T cells
title_full IL-15-independent antiviral function of primary and memory CD8(+) T cells
title_fullStr IL-15-independent antiviral function of primary and memory CD8(+) T cells
title_full_unstemmed IL-15-independent antiviral function of primary and memory CD8(+) T cells
title_short IL-15-independent antiviral function of primary and memory CD8(+) T cells
title_sort il-15-independent antiviral function of primary and memory cd8(+) t cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111818/
https://www.ncbi.nlm.nih.gov/pubmed/15629776
http://dx.doi.org/10.1016/j.virol.2004.10.035
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