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Serine-scanning mutagenesis studies of the C-terminal heptad repeats in the SARS coronavirus S glycoprotein highlight the important role of the short helical region

The fusion subunit of the SARS-CoV S glycoprotein contains two regions of hydrophobic heptad-repeat amino acid sequences that have been shown in biophysical studies to form a six-helix bundle structure typical of the fusion-active core found in Class I viral fusion proteins. Here, we have applied se...

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Detalles Bibliográficos
Autores principales: Follis, Kathryn E., York, Joanne, Nunberg, Jack H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111819/
https://www.ncbi.nlm.nih.gov/pubmed/16081124
http://dx.doi.org/10.1016/j.virol.2005.07.005