An efficient and tunable route to AG7088, a rhinovirus protease inhibitor

Aldol reaction of N,N-dibenzyl valinal with propiolic acid ethyl ester derived lithium reagent provides anti-aminoalcohol 8 and syn-aminoalcohol 9, which are converted into the lactone 6 via two different routes. Alkylation of 6 followed by lactone ring opening afford the acid 2a, which is coupled w...

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Detalles Bibliográficos
Autores principales: Ma, Dawei, Xie, Weiqing, Zou, Bin, Lei, Qiong, Pei, Duanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111835/
https://www.ncbi.nlm.nih.gov/pubmed/32287436
http://dx.doi.org/10.1016/j.tetlet.2004.08.179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111835/
https://www.ncbi.nlm.nih.gov/pubmed/32287436
http://dx.doi.org/10.1016/j.tetlet.2004.08.179

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