Synthesis of a library of glycosylated flavonols

Flavonols are an important class of natural products isolated from plants. Some glycosylated flavonols showed very interesting biological activities. A library of flavonols has been made through Algar–Flynn–Oyamada reaction from 2′-hydroxyacetophenones and benzaldehydes. Glycosylation of these flavo...

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Detalles Bibliográficos
Autores principales: Li, Zhitao, Ngojeh, George, DeWitt, Paul, Zheng, Zhi, Chen, Min, Lainhart, Brendan, Li, Vincent, Felpo, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111846/
https://www.ncbi.nlm.nih.gov/pubmed/32287439
http://dx.doi.org/10.1016/j.tetlet.2008.10.032
Descripción
Sumario:Flavonols are an important class of natural products isolated from plants. Some glycosylated flavonols showed very interesting biological activities. A library of flavonols has been made through Algar–Flynn–Oyamada reaction from 2′-hydroxyacetophenones and benzaldehydes. Glycosylation of these flavonols with various glycosyl donors affords a library of glycosylated flavonols. These compounds are potentially useful pharmacologically active compounds and will be studied for biological activities.

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