Synthesis of a library of glycosylated flavonols

Flavonols are an important class of natural products isolated from plants. Some glycosylated flavonols showed very interesting biological activities. A library of flavonols has been made through Algar–Flynn–Oyamada reaction from 2′-hydroxyacetophenones and benzaldehydes. Glycosylation of these flavo...

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Detalles Bibliográficos
Autores principales: Li, Zhitao, Ngojeh, George, DeWitt, Paul, Zheng, Zhi, Chen, Min, Lainhart, Brendan, Li, Vincent, Felpo, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111846/
https://www.ncbi.nlm.nih.gov/pubmed/32287439
http://dx.doi.org/10.1016/j.tetlet.2008.10.032
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author Li, Zhitao
Ngojeh, George
DeWitt, Paul
Zheng, Zhi
Chen, Min
Lainhart, Brendan
Li, Vincent
Felpo, Peter
author_facet Li, Zhitao
Ngojeh, George
DeWitt, Paul
Zheng, Zhi
Chen, Min
Lainhart, Brendan
Li, Vincent
Felpo, Peter
author_sort Li, Zhitao
collection PubMed
description Flavonols are an important class of natural products isolated from plants. Some glycosylated flavonols showed very interesting biological activities. A library of flavonols has been made through Algar–Flynn–Oyamada reaction from 2′-hydroxyacetophenones and benzaldehydes. Glycosylation of these flavonols with various glycosyl donors affords a library of glycosylated flavonols. These compounds are potentially useful pharmacologically active compounds and will be studied for biological activities.
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spelling pubmed-71118462020-04-02 Synthesis of a library of glycosylated flavonols Li, Zhitao Ngojeh, George DeWitt, Paul Zheng, Zhi Chen, Min Lainhart, Brendan Li, Vincent Felpo, Peter Tetrahedron Lett Article Flavonols are an important class of natural products isolated from plants. Some glycosylated flavonols showed very interesting biological activities. A library of flavonols has been made through Algar–Flynn–Oyamada reaction from 2′-hydroxyacetophenones and benzaldehydes. Glycosylation of these flavonols with various glycosyl donors affords a library of glycosylated flavonols. These compounds are potentially useful pharmacologically active compounds and will be studied for biological activities. Elsevier Ltd. 2008-12-15 2008-10-11 /pmc/articles/PMC7111846/ /pubmed/32287439 http://dx.doi.org/10.1016/j.tetlet.2008.10.032 Text en Copyright © 2008 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Zhitao
Ngojeh, George
DeWitt, Paul
Zheng, Zhi
Chen, Min
Lainhart, Brendan
Li, Vincent
Felpo, Peter
Synthesis of a library of glycosylated flavonols
title Synthesis of a library of glycosylated flavonols
title_full Synthesis of a library of glycosylated flavonols
title_fullStr Synthesis of a library of glycosylated flavonols
title_full_unstemmed Synthesis of a library of glycosylated flavonols
title_short Synthesis of a library of glycosylated flavonols
title_sort synthesis of a library of glycosylated flavonols
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111846/
https://www.ncbi.nlm.nih.gov/pubmed/32287439
http://dx.doi.org/10.1016/j.tetlet.2008.10.032
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