A human coronavirus OC43 variant harboring persistence-associated mutations in the S glycoprotein differentially induces the unfolded protein response in human neurons as compared to wild-type virus

We have reported that human respiratory coronavirus OC43 (HCoV-OC43) is neurotropic and neuroinvasive in humans and mice, and that neurons are the primary target of infection in mice, leading to neurodegenerative disabilities. We now report that an HCoV-OC43 mutant harboring two persistence-associat...

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Detalles Bibliográficos
Autores principales: Favreau, Dominique J., Desforges, Marc, St-Jean, Julien R., Talbot, Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111944/
https://www.ncbi.nlm.nih.gov/pubmed/19846189
http://dx.doi.org/10.1016/j.virol.2009.09.026

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