Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression

Ebola (EBOV) and Marburg virus (MARV) cause severe hemorrhagic fever. The host cell proteases cathepsin B and L activate the Zaire ebolavirus glycoprotein (GP) for cellular entry and constitute potential targets for antiviral intervention. However, it is unclear if different EBOV species and MARV eq...

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Autores principales: Gnirß, Kerstin, Kühl, Annika, Karsten, Christina, Glowacka, Ilona, Bertram, Stephanie, Kaup, Franziska, Hofmann, Heike, Pöhlmann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111950/
https://www.ncbi.nlm.nih.gov/pubmed/22222211
http://dx.doi.org/10.1016/j.virol.2011.11.031

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