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Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens

Infectious bronchitis virus (IBV) replicates in the epithelial cells of trachea and lungs of chicken, however the mechanism of generation of innate immune response against IBV infection in these tissues has not been fully characterized. Our objective was to study innate responses induced early follo...

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Autores principales: Kameka, Amber Marie, Haddadi, Siamak, Kim, Dae Sun, Cork, Susan Catherine, Abdul-Careem, Mohammad Faizal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111962/
https://www.ncbi.nlm.nih.gov/pubmed/24503073
http://dx.doi.org/10.1016/j.virol.2013.12.001
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author Kameka, Amber Marie
Haddadi, Siamak
Kim, Dae Sun
Cork, Susan Catherine
Abdul-Careem, Mohammad Faizal
author_facet Kameka, Amber Marie
Haddadi, Siamak
Kim, Dae Sun
Cork, Susan Catherine
Abdul-Careem, Mohammad Faizal
author_sort Kameka, Amber Marie
collection PubMed
description Infectious bronchitis virus (IBV) replicates in the epithelial cells of trachea and lungs of chicken, however the mechanism of generation of innate immune response against IBV infection in these tissues has not been fully characterized. Our objective was to study innate responses induced early following IBV infection in chickens. Initiation of the transcription of selected innate immune genes such as TLR3, TLR7, MyD88, IL-1β and IFN-β, as well as recruitment of macrophages, were evident following an initial down regulation of some of the observed genes (TLR3, IL-1β, and IFN-γ) in trachea and lung. This initial down-regulation followed by the induction of innate immune response to IBV infection appears to be inadequate for the control of IBV genome accumulation and consequent histopathological changes in these tissues. Potential induction of innate immunity before infection occurs may be necessary to reduce the consequences since vaccine induced immunity is slow to develop.
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spelling pubmed-71119622020-04-02 Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens Kameka, Amber Marie Haddadi, Siamak Kim, Dae Sun Cork, Susan Catherine Abdul-Careem, Mohammad Faizal Virology Article Infectious bronchitis virus (IBV) replicates in the epithelial cells of trachea and lungs of chicken, however the mechanism of generation of innate immune response against IBV infection in these tissues has not been fully characterized. Our objective was to study innate responses induced early following IBV infection in chickens. Initiation of the transcription of selected innate immune genes such as TLR3, TLR7, MyD88, IL-1β and IFN-β, as well as recruitment of macrophages, were evident following an initial down regulation of some of the observed genes (TLR3, IL-1β, and IFN-γ) in trachea and lung. This initial down-regulation followed by the induction of innate immune response to IBV infection appears to be inadequate for the control of IBV genome accumulation and consequent histopathological changes in these tissues. Potential induction of innate immunity before infection occurs may be necessary to reduce the consequences since vaccine induced immunity is slow to develop. Elsevier Inc. 2014-02 2013-12-30 /pmc/articles/PMC7111962/ /pubmed/24503073 http://dx.doi.org/10.1016/j.virol.2013.12.001 Text en Copyright © 2013 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Kameka, Amber Marie
Haddadi, Siamak
Kim, Dae Sun
Cork, Susan Catherine
Abdul-Careem, Mohammad Faizal
Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens
title Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens
title_full Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens
title_fullStr Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens
title_full_unstemmed Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens
title_short Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens
title_sort induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111962/
https://www.ncbi.nlm.nih.gov/pubmed/24503073
http://dx.doi.org/10.1016/j.virol.2013.12.001
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