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The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1—a review
The pathology of 2 zoonotic human viral infections that recently emerged, severe acute respiratory syndrome (SARS) due to coronavirus (SARS-CoV) and avian influenza A subtype H5N1, is reviewed and compared based on the literature and the cases examined by the authors. Pneumocytes are the primary tar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112039/ https://www.ncbi.nlm.nih.gov/pubmed/16564911 http://dx.doi.org/10.1016/j.humpath.2006.01.015 |
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author | Ng, Wai-Fu To, Ka-Fai Lam, William W.L. Ng, Tak-Keung Lee, Kam-Cheong |
author_facet | Ng, Wai-Fu To, Ka-Fai Lam, William W.L. Ng, Tak-Keung Lee, Kam-Cheong |
author_sort | Ng, Wai-Fu |
collection | PubMed |
description | The pathology of 2 zoonotic human viral infections that recently emerged, severe acute respiratory syndrome (SARS) due to coronavirus (SARS-CoV) and avian influenza A subtype H5N1, is reviewed and compared based on the literature and the cases examined by the authors. Pneumocytes are the primary target of infection resulting in diffuse alveolar damage. Systemic cytokine activation results in hemophagocytic syndrome, lymphoid depletion, and skeletal muscle fiber necrosis. Severe acute respiratory syndrome induces a more fibrocellular intra-alveolar organization with a “bronchiolitis obliterans organizing pneumonia”–like pattern and presence of multinucleated histiocytes and pneumocytes. H5N1 causes a more fulminant and necrotizing diffuse alveolar damage with patchy and interstitial paucicellular fibrosis. Severe acute respiratory syndrome associated coronavirus persists in the lung up to the second month, whereas H5N1 persists in the lung up to the third week. Severe acute respiratory syndrome associated coronavirus disseminates to blood, urine, feces, gastrointestinal tract, and liver. There is recent report of possible cerebral involvement by H5N1 and its isolation in the blood, gastrointestinal tract, and cerebrospinal fluid. More pathologic studies are urgently needed. |
format | Online Article Text |
id | pubmed-7112039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71120392020-04-02 The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1—a review Ng, Wai-Fu To, Ka-Fai Lam, William W.L. Ng, Tak-Keung Lee, Kam-Cheong Hum Pathol Article The pathology of 2 zoonotic human viral infections that recently emerged, severe acute respiratory syndrome (SARS) due to coronavirus (SARS-CoV) and avian influenza A subtype H5N1, is reviewed and compared based on the literature and the cases examined by the authors. Pneumocytes are the primary target of infection resulting in diffuse alveolar damage. Systemic cytokine activation results in hemophagocytic syndrome, lymphoid depletion, and skeletal muscle fiber necrosis. Severe acute respiratory syndrome induces a more fibrocellular intra-alveolar organization with a “bronchiolitis obliterans organizing pneumonia”–like pattern and presence of multinucleated histiocytes and pneumocytes. H5N1 causes a more fulminant and necrotizing diffuse alveolar damage with patchy and interstitial paucicellular fibrosis. Severe acute respiratory syndrome associated coronavirus persists in the lung up to the second month, whereas H5N1 persists in the lung up to the third week. Severe acute respiratory syndrome associated coronavirus disseminates to blood, urine, feces, gastrointestinal tract, and liver. There is recent report of possible cerebral involvement by H5N1 and its isolation in the blood, gastrointestinal tract, and cerebrospinal fluid. More pathologic studies are urgently needed. Elsevier Inc. 2006-04 2006-03-27 /pmc/articles/PMC7112039/ /pubmed/16564911 http://dx.doi.org/10.1016/j.humpath.2006.01.015 Text en Copyright © 2006 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Ng, Wai-Fu To, Ka-Fai Lam, William W.L. Ng, Tak-Keung Lee, Kam-Cheong The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1—a review |
title | The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1—a review |
title_full | The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1—a review |
title_fullStr | The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1—a review |
title_full_unstemmed | The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1—a review |
title_short | The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1—a review |
title_sort | comparative pathology of severe acute respiratory syndrome and avian influenza a subtype h5n1—a review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112039/ https://www.ncbi.nlm.nih.gov/pubmed/16564911 http://dx.doi.org/10.1016/j.humpath.2006.01.015 |
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