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Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China

Although rodents are important reservoirs for RNA viruses, to date only one species of rodent coronavirus (CoV) has been identified. Herein, we describe a new CoV, denoted Lucheng Rn rat coronavirus (LRNV), and novel variants of two Betacoronavirus species termed Longquan Aa mouse coronavirus (LAMV)...

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Detalles Bibliográficos
Autores principales: Wang, Wen, Lin, Xian-Dan, Guo, Wen-Ping, Zhou, Run-Hong, Wang, Miao-Ruo, Wang, Cai-Qiao, Ge, Shuang, Mei, Sheng-Hua, Li, Ming-Hui, Shi, Mang, Holmes, Edward C., Zhang, Yong-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112057/
https://www.ncbi.nlm.nih.gov/pubmed/25463600
http://dx.doi.org/10.1016/j.virol.2014.10.017
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author Wang, Wen
Lin, Xian-Dan
Guo, Wen-Ping
Zhou, Run-Hong
Wang, Miao-Ruo
Wang, Cai-Qiao
Ge, Shuang
Mei, Sheng-Hua
Li, Ming-Hui
Shi, Mang
Holmes, Edward C.
Zhang, Yong-Zhen
author_facet Wang, Wen
Lin, Xian-Dan
Guo, Wen-Ping
Zhou, Run-Hong
Wang, Miao-Ruo
Wang, Cai-Qiao
Ge, Shuang
Mei, Sheng-Hua
Li, Ming-Hui
Shi, Mang
Holmes, Edward C.
Zhang, Yong-Zhen
author_sort Wang, Wen
collection PubMed
description Although rodents are important reservoirs for RNA viruses, to date only one species of rodent coronavirus (CoV) has been identified. Herein, we describe a new CoV, denoted Lucheng Rn rat coronavirus (LRNV), and novel variants of two Betacoronavirus species termed Longquan Aa mouse coronavirus (LAMV) and Longquan Rl rat coronavirus (LRLV), that were identified in a survey of 1465 rodents sampled in China during 2011–2013. Phylogenetic analysis revealed that LAMV and LRLV fell into lineage A of the genus Betacoronavirus, which included CoVs discovered in humans and domestic and wild animals. In contrast, LRNV harbored by Rattus norvegicus formed a distinct lineage within the genus Alphacoronavirus in the 3CL(pro), RdRp, and Hel gene trees, but formed a more divergent lineage in the N and S gene trees, indicative of a recombinant origin. Additional recombination events were identified in LRLV. Together, these data suggest that rodents may carry additional unrecognized CoVs.
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spelling pubmed-71120572020-04-02 Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China Wang, Wen Lin, Xian-Dan Guo, Wen-Ping Zhou, Run-Hong Wang, Miao-Ruo Wang, Cai-Qiao Ge, Shuang Mei, Sheng-Hua Li, Ming-Hui Shi, Mang Holmes, Edward C. Zhang, Yong-Zhen Virology Article Although rodents are important reservoirs for RNA viruses, to date only one species of rodent coronavirus (CoV) has been identified. Herein, we describe a new CoV, denoted Lucheng Rn rat coronavirus (LRNV), and novel variants of two Betacoronavirus species termed Longquan Aa mouse coronavirus (LAMV) and Longquan Rl rat coronavirus (LRLV), that were identified in a survey of 1465 rodents sampled in China during 2011–2013. Phylogenetic analysis revealed that LAMV and LRLV fell into lineage A of the genus Betacoronavirus, which included CoVs discovered in humans and domestic and wild animals. In contrast, LRNV harbored by Rattus norvegicus formed a distinct lineage within the genus Alphacoronavirus in the 3CL(pro), RdRp, and Hel gene trees, but formed a more divergent lineage in the N and S gene trees, indicative of a recombinant origin. Additional recombination events were identified in LRLV. Together, these data suggest that rodents may carry additional unrecognized CoVs. Elsevier Inc. 2015-01-01 2014-11-09 /pmc/articles/PMC7112057/ /pubmed/25463600 http://dx.doi.org/10.1016/j.virol.2014.10.017 Text en Copyright © 2014 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wang, Wen
Lin, Xian-Dan
Guo, Wen-Ping
Zhou, Run-Hong
Wang, Miao-Ruo
Wang, Cai-Qiao
Ge, Shuang
Mei, Sheng-Hua
Li, Ming-Hui
Shi, Mang
Holmes, Edward C.
Zhang, Yong-Zhen
Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China
title Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China
title_full Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China
title_fullStr Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China
title_full_unstemmed Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China
title_short Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China
title_sort discovery, diversity and evolution of novel coronaviruses sampled from rodents in china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112057/
https://www.ncbi.nlm.nih.gov/pubmed/25463600
http://dx.doi.org/10.1016/j.virol.2014.10.017
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