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Newcastle disease virus induces G(0)/G(1) cell cycle arrest in asynchronously growing cells

The cell cycle, as a basic cellular process, is conservatively regulated. Consequently, subversion of the host cell replication cycle is a common strategy employed by many viruses to create a cellular environment favorable for viral replication. Newcastle disease virus (NDV) causes disease in poultr...

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Autores principales: Wang, Yan, Wang, Rui, Li, Yanrong, Sun, Yingjie, Song, Cuiping, Zhan, Yuan, Tan, Lei, Liao, Ying, Meng, ChunChun, Qiu, Xusheng, Ding, Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112094/
https://www.ncbi.nlm.nih.gov/pubmed/29793075
http://dx.doi.org/10.1016/j.virol.2018.05.005
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author Wang, Yan
Wang, Rui
Li, Yanrong
Sun, Yingjie
Song, Cuiping
Zhan, Yuan
Tan, Lei
Liao, Ying
Meng, ChunChun
Qiu, Xusheng
Ding, Chan
author_facet Wang, Yan
Wang, Rui
Li, Yanrong
Sun, Yingjie
Song, Cuiping
Zhan, Yuan
Tan, Lei
Liao, Ying
Meng, ChunChun
Qiu, Xusheng
Ding, Chan
author_sort Wang, Yan
collection PubMed
description The cell cycle, as a basic cellular process, is conservatively regulated. Consequently, subversion of the host cell replication cycle is a common strategy employed by many viruses to create a cellular environment favorable for viral replication. Newcastle disease virus (NDV) causes disease in poultry and is also an effective oncolytic agent. However, the effects of NDV infection on cell cycle progression are unknown. In this study, we showed that NDV replication in asynchronized cells resulted in the accumulation of infected cells in the G(0)/G(1) phase of the cell cycle, which benefitted the proliferation of NDV. Examination of various cell cycle-regulatory proteins showed that expression of cyclin D1, was significantly reduced following NDV infection. Importantly, the decreased expression of cyclin D1 was reversed by inhibition of CHOP expression, indicating that induction of the PERK-eIF-2a-ATF4-CHOP signaling pathway was involved in the G(0)/G(1) phase cell cycle arrest observed following NDV infection.
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spelling pubmed-71120942020-04-02 Newcastle disease virus induces G(0)/G(1) cell cycle arrest in asynchronously growing cells Wang, Yan Wang, Rui Li, Yanrong Sun, Yingjie Song, Cuiping Zhan, Yuan Tan, Lei Liao, Ying Meng, ChunChun Qiu, Xusheng Ding, Chan Virology Article The cell cycle, as a basic cellular process, is conservatively regulated. Consequently, subversion of the host cell replication cycle is a common strategy employed by many viruses to create a cellular environment favorable for viral replication. Newcastle disease virus (NDV) causes disease in poultry and is also an effective oncolytic agent. However, the effects of NDV infection on cell cycle progression are unknown. In this study, we showed that NDV replication in asynchronized cells resulted in the accumulation of infected cells in the G(0)/G(1) phase of the cell cycle, which benefitted the proliferation of NDV. Examination of various cell cycle-regulatory proteins showed that expression of cyclin D1, was significantly reduced following NDV infection. Importantly, the decreased expression of cyclin D1 was reversed by inhibition of CHOP expression, indicating that induction of the PERK-eIF-2a-ATF4-CHOP signaling pathway was involved in the G(0)/G(1) phase cell cycle arrest observed following NDV infection. Elsevier Inc. 2018-07 2018-05-26 /pmc/articles/PMC7112094/ /pubmed/29793075 http://dx.doi.org/10.1016/j.virol.2018.05.005 Text en © 2018 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wang, Yan
Wang, Rui
Li, Yanrong
Sun, Yingjie
Song, Cuiping
Zhan, Yuan
Tan, Lei
Liao, Ying
Meng, ChunChun
Qiu, Xusheng
Ding, Chan
Newcastle disease virus induces G(0)/G(1) cell cycle arrest in asynchronously growing cells
title Newcastle disease virus induces G(0)/G(1) cell cycle arrest in asynchronously growing cells
title_full Newcastle disease virus induces G(0)/G(1) cell cycle arrest in asynchronously growing cells
title_fullStr Newcastle disease virus induces G(0)/G(1) cell cycle arrest in asynchronously growing cells
title_full_unstemmed Newcastle disease virus induces G(0)/G(1) cell cycle arrest in asynchronously growing cells
title_short Newcastle disease virus induces G(0)/G(1) cell cycle arrest in asynchronously growing cells
title_sort newcastle disease virus induces g(0)/g(1) cell cycle arrest in asynchronously growing cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112094/
https://www.ncbi.nlm.nih.gov/pubmed/29793075
http://dx.doi.org/10.1016/j.virol.2018.05.005
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