A TRIFfic Perspective on Acute Lung Injury

Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findi...

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Detalles Bibliográficos
Autores principales: Martin, Thomas R., Wurfel, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2008
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112263/
https://www.ncbi.nlm.nih.gov/pubmed/18423191
http://dx.doi.org/10.1016/j.cell.2008.04.006
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author Martin, Thomas R.
Wurfel, Mark M.
author_facet Martin, Thomas R.
Wurfel, Mark M.
author_sort Martin, Thomas R.
collection PubMed
description Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findings provide insight into the molecular pathogenesis of ALI, a condition for which treatment options are currently very limited.
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spelling pubmed-71122632020-04-02 A TRIFfic Perspective on Acute Lung Injury Martin, Thomas R. Wurfel, Mark M. Cell Preview Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findings provide insight into the molecular pathogenesis of ALI, a condition for which treatment options are currently very limited. Elsevier Inc. 2008-04-18 2008-04-17 /pmc/articles/PMC7112263/ /pubmed/18423191 http://dx.doi.org/10.1016/j.cell.2008.04.006 Text en Copyright © 2008 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Preview
Martin, Thomas R.
Wurfel, Mark M.
A TRIFfic Perspective on Acute Lung Injury
title A TRIFfic Perspective on Acute Lung Injury
title_full A TRIFfic Perspective on Acute Lung Injury
title_fullStr A TRIFfic Perspective on Acute Lung Injury
title_full_unstemmed A TRIFfic Perspective on Acute Lung Injury
title_short A TRIFfic Perspective on Acute Lung Injury
title_sort triffic perspective on acute lung injury
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112263/
https://www.ncbi.nlm.nih.gov/pubmed/18423191
http://dx.doi.org/10.1016/j.cell.2008.04.006
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