Circle the Wagons: Circular RNAs Control Innate Immunity

Circular RNAs are generated at low levels from many protein-coding genes. Liu et al. now reveal that many of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR. Upon viral infection, circular RNAs are globally degraded to release PKR, which becomes activated to a...

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Detalles Bibliográficos
Autor principal: Wilusz, Jeremy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112311/
https://www.ncbi.nlm.nih.gov/pubmed/31051101
http://dx.doi.org/10.1016/j.cell.2019.04.020
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author Wilusz, Jeremy E.
author_facet Wilusz, Jeremy E.
author_sort Wilusz, Jeremy E.
collection PubMed
description Circular RNAs are generated at low levels from many protein-coding genes. Liu et al. now reveal that many of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR. Upon viral infection, circular RNAs are globally degraded to release PKR, which becomes activated to aid in the immune response.
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spelling pubmed-71123112020-04-02 Circle the Wagons: Circular RNAs Control Innate Immunity Wilusz, Jeremy E. Cell Article Circular RNAs are generated at low levels from many protein-coding genes. Liu et al. now reveal that many of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR. Upon viral infection, circular RNAs are globally degraded to release PKR, which becomes activated to aid in the immune response. Elsevier Inc. 2019-05-02 2019-05-02 /pmc/articles/PMC7112311/ /pubmed/31051101 http://dx.doi.org/10.1016/j.cell.2019.04.020 Text en © 2019 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wilusz, Jeremy E.
Circle the Wagons: Circular RNAs Control Innate Immunity
title Circle the Wagons: Circular RNAs Control Innate Immunity
title_full Circle the Wagons: Circular RNAs Control Innate Immunity
title_fullStr Circle the Wagons: Circular RNAs Control Innate Immunity
title_full_unstemmed Circle the Wagons: Circular RNAs Control Innate Immunity
title_short Circle the Wagons: Circular RNAs Control Innate Immunity
title_sort circle the wagons: circular rnas control innate immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112311/
https://www.ncbi.nlm.nih.gov/pubmed/31051101
http://dx.doi.org/10.1016/j.cell.2019.04.020
work_keys_str_mv AT wiluszjeremye circlethewagonscircularrnascontrolinnateimmunity

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