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Circle the Wagons: Circular RNAs Control Innate Immunity
Circular RNAs are generated at low levels from many protein-coding genes. Liu et al. now reveal that many of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR. Upon viral infection, circular RNAs are globally degraded to release PKR, which becomes activated to a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Inc.
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112311/ https://www.ncbi.nlm.nih.gov/pubmed/31051101 http://dx.doi.org/10.1016/j.cell.2019.04.020 |