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Promising approaches for the treatment and prevention of viral respiratory illnesses

Viral respiratory tract infections are the most common human ailments, leading to enormous health and economic burden. Hundreds of viral species and subtypes have been associated with these conditions, with influenza viruses, respiratory syncytial virus, and rhinoviruses being the most frequent and...

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Autores principales: Papadopoulos, Nikolaos G., Megremis, Spyridon, Kitsioulis, Nikolaos A., Vangelatou, Olympia, West, Peter, Xepapadaki, Paraskevi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Academy of Allergy, Asthma & Immunology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112313/
https://www.ncbi.nlm.nih.gov/pubmed/28739285
http://dx.doi.org/10.1016/j.jaci.2017.07.001
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author Papadopoulos, Nikolaos G.
Megremis, Spyridon
Kitsioulis, Nikolaos A.
Vangelatou, Olympia
West, Peter
Xepapadaki, Paraskevi
author_facet Papadopoulos, Nikolaos G.
Megremis, Spyridon
Kitsioulis, Nikolaos A.
Vangelatou, Olympia
West, Peter
Xepapadaki, Paraskevi
author_sort Papadopoulos, Nikolaos G.
collection PubMed
description Viral respiratory tract infections are the most common human ailments, leading to enormous health and economic burden. Hundreds of viral species and subtypes have been associated with these conditions, with influenza viruses, respiratory syncytial virus, and rhinoviruses being the most frequent and with the highest burden. When considering prevention or treatment of viral respiratory tract infections, potential targets include the causative pathogens themselves but also the immune response, disease transmission, or even just the symptoms. Strategies targeting all these aspects are developing concurrently, and several novel and promising approaches are emerging. In this perspective we overview the entire range of options and highlight some of the most promising approaches, including new antiviral agents, symptomatic or immunomodulatory drugs, the re-emergence of natural remedies, and vaccines and public health policies toward prevention. Wide-scale prevention through immunization appears to be within reach for respiratory syncytial virus and promising for influenza virus, whereas additional effort is needed in regard to rhinovirus, as well as other respiratory tract viruses.
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spelling pubmed-71123132020-04-02 Promising approaches for the treatment and prevention of viral respiratory illnesses Papadopoulos, Nikolaos G. Megremis, Spyridon Kitsioulis, Nikolaos A. Vangelatou, Olympia West, Peter Xepapadaki, Paraskevi J Allergy Clin Immunol Article Viral respiratory tract infections are the most common human ailments, leading to enormous health and economic burden. Hundreds of viral species and subtypes have been associated with these conditions, with influenza viruses, respiratory syncytial virus, and rhinoviruses being the most frequent and with the highest burden. When considering prevention or treatment of viral respiratory tract infections, potential targets include the causative pathogens themselves but also the immune response, disease transmission, or even just the symptoms. Strategies targeting all these aspects are developing concurrently, and several novel and promising approaches are emerging. In this perspective we overview the entire range of options and highlight some of the most promising approaches, including new antiviral agents, symptomatic or immunomodulatory drugs, the re-emergence of natural remedies, and vaccines and public health policies toward prevention. Wide-scale prevention through immunization appears to be within reach for respiratory syncytial virus and promising for influenza virus, whereas additional effort is needed in regard to rhinovirus, as well as other respiratory tract viruses. American Academy of Allergy, Asthma & Immunology 2017-10 2017-07-21 /pmc/articles/PMC7112313/ /pubmed/28739285 http://dx.doi.org/10.1016/j.jaci.2017.07.001 Text en © 2017 American Academy of Allergy, Asthma & Immunology. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Papadopoulos, Nikolaos G.
Megremis, Spyridon
Kitsioulis, Nikolaos A.
Vangelatou, Olympia
West, Peter
Xepapadaki, Paraskevi
Promising approaches for the treatment and prevention of viral respiratory illnesses
title Promising approaches for the treatment and prevention of viral respiratory illnesses
title_full Promising approaches for the treatment and prevention of viral respiratory illnesses
title_fullStr Promising approaches for the treatment and prevention of viral respiratory illnesses
title_full_unstemmed Promising approaches for the treatment and prevention of viral respiratory illnesses
title_short Promising approaches for the treatment and prevention of viral respiratory illnesses
title_sort promising approaches for the treatment and prevention of viral respiratory illnesses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112313/
https://www.ncbi.nlm.nih.gov/pubmed/28739285
http://dx.doi.org/10.1016/j.jaci.2017.07.001
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