Similar recombination-activating gene (RAG) mutations result in similar immunobiological effects but in different clinical phenotypes

BACKGROUND: V(D)J recombination takes place during lymphocyte development to generate a large repertoire of T- and B-cell receptors. Mutations in recombination-activating gene 1 (RAG1) and RAG2 result in loss or reduction of V(D)J recombination. It is known that different mutations in RAG genes vary...

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Detalles Bibliográficos
Autores principales: IJspeert, Hanna, Driessen, Gertjan J., Moorhouse, Michael J., Hartwig, Nico G., Wolska-Kusnierz, Beata, Kalwak, Krzysztof, Pituch-Noworolska, Anna, Kondratenko, Irina, van Montfrans, Joris M., Mejstrikova, Ester, Lankester, Arjan C., Langerak, Anton W., van Gent, Dik C., Stubbs, Andrew P., van Dongen, Jacques J.M., van der Burg, Mirjam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112318/
https://www.ncbi.nlm.nih.gov/pubmed/24418478
http://dx.doi.org/10.1016/j.jaci.2013.11.028

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