Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high lethality due to acute respiratory distress syndrome. Here we report that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI). We show that TLR4-TRIF-TRAF6 signa...

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Detalles Bibliográficos
Autores principales: Imai, Yumiko, Kuba, Keiji, Neely, G. Greg, Yaghubian-Malhami, Rubina, Perkmann, Thomas, van Loo, Geert, Ermolaeva, Maria, Veldhuizen, Ruud, Leung, Y.H. Connie, Wang, Hongliang, Liu, Haolin, Sun, Yang, Pasparakis, Manolis, Kopf, Manfred, Mech, Christin, Bavari, Sina, Peiris, J.S. Malik, Slutsky, Arthur S., Akira, Shizuo, Hultqvist, Malin, Holmdahl, Rikard, Nicholls, John, Jiang, Chengyu, Binder, Christoph J., Penninger, Josef M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112336/
https://www.ncbi.nlm.nih.gov/pubmed/18423196
http://dx.doi.org/10.1016/j.cell.2008.02.043

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