Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia

Recent advances in our understanding of stem/progenitor cells and their potential to repair damaged organs offer the possibility of cell-based treatments for neonatal lung injury. This review summarizes basic concepts of stem/progenitor cell biology and discusses the recent advances and challenges o...

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Detalles Bibliográficos
Autores principales: O'Reilly, Megan, Thébaud, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112346/
https://www.ncbi.nlm.nih.gov/pubmed/22954277
http://dx.doi.org/10.1016/j.clp.2012.06.009
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author O'Reilly, Megan
Thébaud, Bernard
author_facet O'Reilly, Megan
Thébaud, Bernard
author_sort O'Reilly, Megan
collection PubMed
description Recent advances in our understanding of stem/progenitor cells and their potential to repair damaged organs offer the possibility of cell-based treatments for neonatal lung injury. This review summarizes basic concepts of stem/progenitor cell biology and discusses the recent advances and challenges of cell-based therapies for lung diseases, with a particular focus on bronchopulmonary dysplasia (BPD), a form of chronic lung disease that primarily affects very preterm infants. Despite advances in perinatal care, BPD still remains the most common complication of extreme prematurity, and there is no specific treatment.
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spelling pubmed-71123462020-04-02 Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia O'Reilly, Megan Thébaud, Bernard Clin Perinatol Article Recent advances in our understanding of stem/progenitor cells and their potential to repair damaged organs offer the possibility of cell-based treatments for neonatal lung injury. This review summarizes basic concepts of stem/progenitor cell biology and discusses the recent advances and challenges of cell-based therapies for lung diseases, with a particular focus on bronchopulmonary dysplasia (BPD), a form of chronic lung disease that primarily affects very preterm infants. Despite advances in perinatal care, BPD still remains the most common complication of extreme prematurity, and there is no specific treatment. Elsevier Inc. 2012-09 2012-09-04 /pmc/articles/PMC7112346/ /pubmed/22954277 http://dx.doi.org/10.1016/j.clp.2012.06.009 Text en Copyright © 2012 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
O'Reilly, Megan
Thébaud, Bernard
Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia
title Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia
title_full Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia
title_fullStr Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia
title_full_unstemmed Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia
title_short Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia
title_sort cell-based strategies to reconstitute lung function in infants with severe bronchopulmonary dysplasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112346/
https://www.ncbi.nlm.nih.gov/pubmed/22954277
http://dx.doi.org/10.1016/j.clp.2012.06.009
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