Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin aga...

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Autores principales: Cinatl, J, Morgenstern, B, Bauer, G, Chandra, P, Rabenau, H, Doerr, HW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112442/
https://www.ncbi.nlm.nih.gov/pubmed/12814717
http://dx.doi.org/10.1016/S0140-6736(03)13615-X
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author Cinatl, J
Morgenstern, B
Bauer, G
Chandra, P
Rabenau, H
Doerr, HW
author_facet Cinatl, J
Morgenstern, B
Bauer, G
Chandra, P
Rabenau, H
Doerr, HW
author_sort Cinatl, J
collection PubMed
description The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.
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spelling pubmed-71124422020-04-02 Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus Cinatl, J Morgenstern, B Bauer, G Chandra, P Rabenau, H Doerr, HW Lancet Article The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS. Elsevier Ltd. 2003-06-14 2003-06-14 /pmc/articles/PMC7112442/ /pubmed/12814717 http://dx.doi.org/10.1016/S0140-6736(03)13615-X Text en Copyright © 2003 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Cinatl, J
Morgenstern, B
Bauer, G
Chandra, P
Rabenau, H
Doerr, HW
Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
title Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
title_full Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
title_fullStr Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
title_full_unstemmed Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
title_short Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
title_sort glycyrrhizin, an active component of liquorice roots, and replication of sars-associated coronavirus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112442/
https://www.ncbi.nlm.nih.gov/pubmed/12814717
http://dx.doi.org/10.1016/S0140-6736(03)13615-X
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