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Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases
Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to balance cellular hydrogen peroxide (H(2)O(2)) levels, which are essential for cell signaling and metabolism and act as a regulator of redox signaling. Redox signaling is a critical component of cell signaling pat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112520/ https://www.ncbi.nlm.nih.gov/pubmed/27130805 http://dx.doi.org/10.1016/j.pharmthera.2016.03.018 |
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author | Park, Mi Hee Jo, MiRan Kim, Yu Ri Lee, Chong-Kil Hong, Jin Tae |
author_facet | Park, Mi Hee Jo, MiRan Kim, Yu Ri Lee, Chong-Kil Hong, Jin Tae |
author_sort | Park, Mi Hee |
collection | PubMed |
description | Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to balance cellular hydrogen peroxide (H(2)O(2)) levels, which are essential for cell signaling and metabolism and act as a regulator of redox signaling. Redox signaling is a critical component of cell signaling pathways that are involved in the regulation of cell growth, metabolism, hormone signaling, immune regulation and variety of other physiological functions. Early studies demonstrated that PRDXs regulates cell growth, metabolism and immune regulation and therefore involved in the pathologic regulator or protectant of several cancers, neurodegenerative diseases and inflammatory diseases. Oxidative stress and antioxidant systems are important regulators of redox signaling regulated diseases. In addition, thiol-based redox systems through peroxiredoxins have been demonstrated to regulate several redox-dependent process related diseases. In this review article, we will discuss recent findings regarding PRDXs in the development of diseases and further discuss therapeutic approaches targeting PRDXs. Moreover, we will suggest that PRDXs could be targets of several diseases and the therapeutic agents for targeting PRDXs may have potential beneficial effects for the treatment of cancers, neurodegenerative diseases and inflammatory diseases. Future research should open new avenues for the design of novel therapeutic approaches targeting PRDXs. |
format | Online Article Text |
id | pubmed-7112520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71125202020-04-02 Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases Park, Mi Hee Jo, MiRan Kim, Yu Ri Lee, Chong-Kil Hong, Jin Tae Pharmacol Ther Associate editor: I. Kimura Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to balance cellular hydrogen peroxide (H(2)O(2)) levels, which are essential for cell signaling and metabolism and act as a regulator of redox signaling. Redox signaling is a critical component of cell signaling pathways that are involved in the regulation of cell growth, metabolism, hormone signaling, immune regulation and variety of other physiological functions. Early studies demonstrated that PRDXs regulates cell growth, metabolism and immune regulation and therefore involved in the pathologic regulator or protectant of several cancers, neurodegenerative diseases and inflammatory diseases. Oxidative stress and antioxidant systems are important regulators of redox signaling regulated diseases. In addition, thiol-based redox systems through peroxiredoxins have been demonstrated to regulate several redox-dependent process related diseases. In this review article, we will discuss recent findings regarding PRDXs in the development of diseases and further discuss therapeutic approaches targeting PRDXs. Moreover, we will suggest that PRDXs could be targets of several diseases and the therapeutic agents for targeting PRDXs may have potential beneficial effects for the treatment of cancers, neurodegenerative diseases and inflammatory diseases. Future research should open new avenues for the design of novel therapeutic approaches targeting PRDXs. Elsevier Inc. 2016-07 2016-04-26 /pmc/articles/PMC7112520/ /pubmed/27130805 http://dx.doi.org/10.1016/j.pharmthera.2016.03.018 Text en © 2016 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Associate editor: I. Kimura Park, Mi Hee Jo, MiRan Kim, Yu Ri Lee, Chong-Kil Hong, Jin Tae Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases |
title | Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases |
title_full | Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases |
title_fullStr | Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases |
title_full_unstemmed | Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases |
title_short | Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases |
title_sort | roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases |
topic | Associate editor: I. Kimura |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112520/ https://www.ncbi.nlm.nih.gov/pubmed/27130805 http://dx.doi.org/10.1016/j.pharmthera.2016.03.018 |
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