Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases

The entire human population is at risk of infectious diseases worldwide. Thus far, the diagnosis and treatment of human infectious diseases at the molecular and nanoscale levels have been extremely challenging tasks because of the lack of effective probes to identify and recognize biomarkers of path...

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Autores principales: Pan, Qin, Luo, Fengling, Liu, Min, Zhang, Xiao-Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Infection Association. Published by Elsevier Ltd. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112547/
https://www.ncbi.nlm.nih.gov/pubmed/29746951
http://dx.doi.org/10.1016/j.jinf.2018.04.007
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author Pan, Qin
Luo, Fengling
Liu, Min
Zhang, Xiao-Lian
author_facet Pan, Qin
Luo, Fengling
Liu, Min
Zhang, Xiao-Lian
author_sort Pan, Qin
collection PubMed
description The entire human population is at risk of infectious diseases worldwide. Thus far, the diagnosis and treatment of human infectious diseases at the molecular and nanoscale levels have been extremely challenging tasks because of the lack of effective probes to identify and recognize biomarkers of pathogens. Oligonucleotide aptamers are a class of small nucleic acid ligands that are composed of single-stranded DNA (ssDNA) or RNA and act as affinity probes or molecular recognition elements for a variety of targets. These aptamers have an exciting potential for diagnose and/or treatment of specific diseases. In this review, we highlight areas where aptamers have been developed as diagnostic and therapeutic agents for both bacterial and viral infectious diseases as well as aptamer-based detection.
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spelling pubmed-71125472020-04-02 Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases Pan, Qin Luo, Fengling Liu, Min Zhang, Xiao-Lian J Infect Article The entire human population is at risk of infectious diseases worldwide. Thus far, the diagnosis and treatment of human infectious diseases at the molecular and nanoscale levels have been extremely challenging tasks because of the lack of effective probes to identify and recognize biomarkers of pathogens. Oligonucleotide aptamers are a class of small nucleic acid ligands that are composed of single-stranded DNA (ssDNA) or RNA and act as affinity probes or molecular recognition elements for a variety of targets. These aptamers have an exciting potential for diagnose and/or treatment of specific diseases. In this review, we highlight areas where aptamers have been developed as diagnostic and therapeutic agents for both bacterial and viral infectious diseases as well as aptamer-based detection. The British Infection Association. Published by Elsevier Ltd. 2018-08 2018-05-07 /pmc/articles/PMC7112547/ /pubmed/29746951 http://dx.doi.org/10.1016/j.jinf.2018.04.007 Text en © 2018 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Pan, Qin
Luo, Fengling
Liu, Min
Zhang, Xiao-Lian
Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases
title Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases
title_full Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases
title_fullStr Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases
title_full_unstemmed Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases
title_short Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases
title_sort oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112547/
https://www.ncbi.nlm.nih.gov/pubmed/29746951
http://dx.doi.org/10.1016/j.jinf.2018.04.007
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