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Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome
Lipids were long believed to have a structural role in biomembranes and a role in energy storage utilizing cellular lipid droplets and plasma lipoproteins. Research over the last decades has identified an additional role of lipids in cellular signaling, membrane microdomain organization and dynamics...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112618/ https://www.ncbi.nlm.nih.gov/pubmed/19638285 http://dx.doi.org/10.1016/j.plipres.2009.07.003 |
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author | van der Meer-Janssen, Ynske P.M. van Galen, Josse Batenburg, Joseph J. Helms, J. Bernd |
author_facet | van der Meer-Janssen, Ynske P.M. van Galen, Josse Batenburg, Joseph J. Helms, J. Bernd |
author_sort | van der Meer-Janssen, Ynske P.M. |
collection | PubMed |
description | Lipids were long believed to have a structural role in biomembranes and a role in energy storage utilizing cellular lipid droplets and plasma lipoproteins. Research over the last decades has identified an additional role of lipids in cellular signaling, membrane microdomain organization and dynamics, and membrane trafficking. These properties make lipids an attractive target for pathogens to modulate host cell processes in order to allow their survival and replication. In this review we will summarize the often ingenious strategies of pathogens to modify the lipid homeostasis of host cells, allowing them to divert cellular processes. To this end pathogens take full advantage of the complexity of the lipidome. The examples are categorized in generalized and emerging principles describing the involvement of lipids in host–pathogen interactions. Several pathogens are described that simultaneously induce multiple changes in the host cell signaling and trafficking mechanisms. Elucidation of these pathogen-induced changes may have important implications for drug development. The emergence of high-throughput lipidomic techniques will allow the description of changes of the host cell lipidome at the level of individual molecular lipid species and the identification of lipid biomarkers. |
format | Online Article Text |
id | pubmed-7112618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71126182020-04-02 Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome van der Meer-Janssen, Ynske P.M. van Galen, Josse Batenburg, Joseph J. Helms, J. Bernd Prog Lipid Res Article Lipids were long believed to have a structural role in biomembranes and a role in energy storage utilizing cellular lipid droplets and plasma lipoproteins. Research over the last decades has identified an additional role of lipids in cellular signaling, membrane microdomain organization and dynamics, and membrane trafficking. These properties make lipids an attractive target for pathogens to modulate host cell processes in order to allow their survival and replication. In this review we will summarize the often ingenious strategies of pathogens to modify the lipid homeostasis of host cells, allowing them to divert cellular processes. To this end pathogens take full advantage of the complexity of the lipidome. The examples are categorized in generalized and emerging principles describing the involvement of lipids in host–pathogen interactions. Several pathogens are described that simultaneously induce multiple changes in the host cell signaling and trafficking mechanisms. Elucidation of these pathogen-induced changes may have important implications for drug development. The emergence of high-throughput lipidomic techniques will allow the description of changes of the host cell lipidome at the level of individual molecular lipid species and the identification of lipid biomarkers. Elsevier Ltd. 2010-01 2009-07-26 /pmc/articles/PMC7112618/ /pubmed/19638285 http://dx.doi.org/10.1016/j.plipres.2009.07.003 Text en Copyright © 2009 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article van der Meer-Janssen, Ynske P.M. van Galen, Josse Batenburg, Joseph J. Helms, J. Bernd Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome |
title | Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome |
title_full | Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome |
title_fullStr | Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome |
title_full_unstemmed | Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome |
title_short | Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome |
title_sort | lipids in host–pathogen interactions: pathogens exploit the complexity of the host cell lipidome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112618/ https://www.ncbi.nlm.nih.gov/pubmed/19638285 http://dx.doi.org/10.1016/j.plipres.2009.07.003 |
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