Genomic organization and adaptive evolution of IGHC genes in marine mammals

Immunoglobulins are important elements of the adaptive immune system that bind to an immense variety of microbial antigens to neutralize infectivity and specify effector functions. In the present study, the immunoglobulin heavy chain constant region (IGHC) genes from marine mammals were identified a...

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Detalles Bibliográficos
Autores principales: Li, Lili, Rong, Xinghua, Li, Guiting, Wang, Yingying, Chen, Bingyao, Ren, Wenhua, Yang, Guang, Xu, Shixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112648/
https://www.ncbi.nlm.nih.gov/pubmed/29723770
http://dx.doi.org/10.1016/j.molimm.2018.04.011
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author Li, Lili
Rong, Xinghua
Li, Guiting
Wang, Yingying
Chen, Bingyao
Ren, Wenhua
Yang, Guang
Xu, Shixia
author_facet Li, Lili
Rong, Xinghua
Li, Guiting
Wang, Yingying
Chen, Bingyao
Ren, Wenhua
Yang, Guang
Xu, Shixia
author_sort Li, Lili
collection PubMed
description Immunoglobulins are important elements of the adaptive immune system that bind to an immense variety of microbial antigens to neutralize infectivity and specify effector functions. In the present study, the immunoglobulin heavy chain constant region (IGHC) genes from marine mammals were identified and compared with those of their terrestrial relatives to explore their genomic organization and evolutionary characteristics. The genomic organization of marine mammal IGHC genes was shown to be conservative with other eutherian mammals. Stronger signals of positive selection on IGHC were revealed in terrestrial mammals than that in marine mammals with the branch-site model, displaying different selective pressure, which might suggest their divergent adaptations to contrasted environments.
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spelling pubmed-71126482020-04-02 Genomic organization and adaptive evolution of IGHC genes in marine mammals Li, Lili Rong, Xinghua Li, Guiting Wang, Yingying Chen, Bingyao Ren, Wenhua Yang, Guang Xu, Shixia Mol Immunol Article Immunoglobulins are important elements of the adaptive immune system that bind to an immense variety of microbial antigens to neutralize infectivity and specify effector functions. In the present study, the immunoglobulin heavy chain constant region (IGHC) genes from marine mammals were identified and compared with those of their terrestrial relatives to explore their genomic organization and evolutionary characteristics. The genomic organization of marine mammal IGHC genes was shown to be conservative with other eutherian mammals. Stronger signals of positive selection on IGHC were revealed in terrestrial mammals than that in marine mammals with the branch-site model, displaying different selective pressure, which might suggest their divergent adaptations to contrasted environments. Elsevier Ltd. 2018-07 2018-05-26 /pmc/articles/PMC7112648/ /pubmed/29723770 http://dx.doi.org/10.1016/j.molimm.2018.04.011 Text en © 2018 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Lili
Rong, Xinghua
Li, Guiting
Wang, Yingying
Chen, Bingyao
Ren, Wenhua
Yang, Guang
Xu, Shixia
Genomic organization and adaptive evolution of IGHC genes in marine mammals
title Genomic organization and adaptive evolution of IGHC genes in marine mammals
title_full Genomic organization and adaptive evolution of IGHC genes in marine mammals
title_fullStr Genomic organization and adaptive evolution of IGHC genes in marine mammals
title_full_unstemmed Genomic organization and adaptive evolution of IGHC genes in marine mammals
title_short Genomic organization and adaptive evolution of IGHC genes in marine mammals
title_sort genomic organization and adaptive evolution of ighc genes in marine mammals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112648/
https://www.ncbi.nlm.nih.gov/pubmed/29723770
http://dx.doi.org/10.1016/j.molimm.2018.04.011
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