Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood. Dividing lymphocytes typically rely on aerobic glycolysis over oxidative phosphorylation for energy. Here we report that GCBCs...

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Detalles Bibliográficos
Autores principales: Weisel, Florian J., Mullett, Steven J., Elsner, Rebecca A., Menk, Ashley V., Trivedi, Nikita, Luo, Wei, Wikenheiser, Daniel, Hawse, William F., Chikina, Maria, Smita, Shuchi, Conter, Laura J., Joachim, Stephen M., Wendell, Stacy G., Jurczak, Michael J., Winkler, Thomas H., Delgoffe, Greg M., Shlomchik, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112716/
https://www.ncbi.nlm.nih.gov/pubmed/32066950
http://dx.doi.org/10.1038/s41590-020-0598-4

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