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Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells

The transcriptional repressors Polycomb repressive complex 1 (PRC1) and PRC2 are required to maintain cell fate during embryonic development. PRC1 and PRC2 catalyze distinct histone modifications, establishing repressive chromatin at shared targets. How PRC1, which consists of canonical PRC1 (cPRC1)...

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Detalles Bibliográficos
Autores principales:	Zepeda-Martinez, J. A., Pribitzer, C., Wang, J., Bsteh, D., Golumbeanu, S., Zhao, Q., Burkard, T. R., Reichholf, B., Rhie, S. K., Jude, J., Moussa, H. F., Zuber, J., Bell, O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112768/ https://www.ncbi.nlm.nih.gov/pubmed/32270030 http://dx.doi.org/10.1126/sciadv.aax5692

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