Cargando…

Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells

The transcriptional repressors Polycomb repressive complex 1 (PRC1) and PRC2 are required to maintain cell fate during embryonic development. PRC1 and PRC2 catalyze distinct histone modifications, establishing repressive chromatin at shared targets. How PRC1, which consists of canonical PRC1 (cPRC1)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zepeda-Martinez, J. A., Pribitzer, C., Wang, J., Bsteh, D., Golumbeanu, S., Zhao, Q., Burkard, T. R., Reichholf, B., Rhie, S. K., Jude, J., Moussa, H. F., Zuber, J., Bell, O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112768/ https://www.ncbi.nlm.nih.gov/pubmed/32270030 http://dx.doi.org/10.1126/sciadv.aax5692

Ejemplares similares

Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
por: Moussa, Hagar F., et al.
Publicado: (2019)

Independent domains for recruitment of PRC1 and PRC2 by human XIST
por: Dixon-McDougall, Thomas, et al.
Publicado: (2021)

Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements
por: Kahn, Tatyana G., et al.
Publicado: (2016)

PRC1 preserves epidermal tissue integrity independently of PRC2
por: Cohen, Idan, et al.
Publicado: (2019)

Structure and Function of the Polycomb Repressive Complexes PRC1 and PRC2
por: Angrand, Pierre-Olivier
Publicado: (2022)

PRC1 uncomplexed
por: Schouten, Sanne, et al.
Publicado: (2022)

PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1
por: Glancy, Eleanor, et al.
Publicado: (2023)

PRC1 sustains the integrity of neural fate in the absence of PRC2 function
por: Sawai, Ayana, et al.
Publicado: (2022)

PRC1 and RACGAP1 are Diagnostic Biomarkers of Early HCC and PRC1 Drives Self-Renewal of Liver Cancer Stem Cells
por: Liao, Shixin, et al.
Publicado: (2022)

Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes
por: Zhen, Chao Yu, et al.
Publicado: (2014)

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
por: Ku, Manching, et al.
Publicado: (2008)

Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes
por: Sugishita, Hiroki, et al.
Publicado: (2021)

PRC2 is high maintenance
por: Yu, Jia-Ray, et al.
Publicado: (2019)

A dimeric state for PRC2
por: Davidovich, Chen, et al.
Publicado: (2014)

Reprogramming CBX8-PRC1 function with a positive allosteric modulator
por: Suh, Junghyun L., et al.
Publicado: (2022)

PRC1 and PRC2 Are Not Required for Targeting of H2A.Z to Developmental Genes in Embryonic Stem Cells
por: Illingworth, Robert S., et al.
Publicado: (2012)

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation
por: Blackledge, Neil P., et al.
Publicado: (2014)

CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR
por: Sharma, Adhikarimayum Lakhikumar, et al.
Publicado: (2020)

The influence of stationary synaptic activity on the PRC
por: Garcia, Guadalupe C, et al.
Publicado: (2011)

Changes in PRC1 activity during interphase modulate lineage transition in pluripotent cells
por: Asenjo, Helena G., et al.
Publicado: (2023)

Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
por: Farley, Sean J., et al.
Publicado: (2022)

Is it time to take R(epressive) out of PRC1?
por: Wang, Dongmei, et al.
Publicado: (2019)

Validation of the solution structure of dimerization domain of PRC1
por: Tan, Fei, et al.
Publicado: (2022)

RAWUL: A new ubiquitin-like domain in PRC1 Ring finger proteins that unveils putative plant and worm PRC1 orthologs
por: Sanchez-Pulido, Luis, et al.
Publicado: (2008)

PRC1 Catalytic Activity Is Central to Polycomb System Function
por: Blackledge, Neil P., et al.
Publicado: (2020)

PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
por: Sato, Teruyuki, et al.
Publicado: (2013)

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
por: von Schimmelmann, Melanie, et al.
Publicado: (2016)

Mitotic Inheritance of PRC2-Mediated Silencing: Mechanistic Insights and Developmental Perspectives
por: Hugues, Alice, et al.
Publicado: (2020)

PRC2 functions in development and congenital disorders
por: Deevy, Orla, et al.
Publicado: (2019)

Regulation of histone methylation by automethylation of PRC2
por: Wang, Xueyin, et al.
Publicado: (2019)

Cooperative DNA looping by PRC2 complexes
por: Lin, Xingcheng, et al.
Publicado: (2021)

Activation of automethylated PRC2 by dimerization on chromatin
por: Sauer, Paul V., et al.
Publicado: (2023)

PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs
por: Shan, Yongli, et al.
Publicado: (2017)

Loss of PRC2 subunits primes lineage choice during exit of pluripotency
por: Loh, Chet H., et al.
Publicado: (2021)

Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome
por: McGinty, Robert K., et al.
Publicado: (2014)

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
por: Cooper, Sarah, et al.
Publicado: (2016)

Identification of MltG as a Prc Protease Substrate Whose Dysregulation Contributes to the Conditional Growth Defect of Prc-Deficient Escherichia coli
por: Hsu, Po-Chuen, et al.
Publicado: (2020)

Chromatin Interaction Analyses Elucidate PRC2-bound Silencers’ Roles in Mouse Development
por: Ngan, Chew Yee, et al.
Publicado: (2020)

PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment
por: Takano, Junichiro, et al.
Publicado: (2022)

The interaction of PRC2 with RNA or chromatin is mutually antagonistic
por: Beltran, Manuel, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_bqg38qf28k4knohh9gp8etc5dk