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Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year

OBJECTIVE: To evaluate the oscillations on the viral detection in adenotonsillar tissues from patients with chronic adenotonsillar diseases as an indicia of the presence of persistent viral infections or acute subclinical infections. STUDY DESIGN: Cross-sectional prospective study. SETTING: Tertiary...

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Autores principales: Proença-Módena, José Luiz, Buzatto, Guilherme P., Paula, Flávia E., Saturno, Tamara H., Delcaro, Luana S., Prates, Mirela C., Tamashiro, Edwin, Valera, Fabiana C.P., Arruda, Eurico, Anselmo-Lima, Wilma T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ireland Ltd. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112801/
https://www.ncbi.nlm.nih.gov/pubmed/25128448
http://dx.doi.org/10.1016/j.ijporl.2014.07.015
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author Proença-Módena, José Luiz
Buzatto, Guilherme P.
Paula, Flávia E.
Saturno, Tamara H.
Delcaro, Luana S.
Prates, Mirela C.
Tamashiro, Edwin
Valera, Fabiana C.P.
Arruda, Eurico
Anselmo-Lima, Wilma T.
author_facet Proença-Módena, José Luiz
Buzatto, Guilherme P.
Paula, Flávia E.
Saturno, Tamara H.
Delcaro, Luana S.
Prates, Mirela C.
Tamashiro, Edwin
Valera, Fabiana C.P.
Arruda, Eurico
Anselmo-Lima, Wilma T.
author_sort Proença-Módena, José Luiz
collection PubMed
description OBJECTIVE: To evaluate the oscillations on the viral detection in adenotonsillar tissues from patients with chronic adenotonsillar diseases as an indicia of the presence of persistent viral infections or acute subclinical infections. STUDY DESIGN: Cross-sectional prospective study. SETTING: Tertiary hospital. METHODS: The fluctuations of respiratory virus detection were compared to the major climatic variables during a two-year period using adenoids and palatine tonsils from 172 children with adenotonsillar hypertrophy and clinical evidence of obstructive sleep apnoea syndrome or recurrent adenotonsillitis, without symptoms of acute respiratory infection (ARI), by TaqMan real-time PCR. RESULTS: The rate of detection of at least one respiratory virus in adenotonsillar tissue was 87%. The most frequently detected viruses were human adenovirus in 52.8%, human enterovirus in 47.2%, human rhinovirus in 33.8%, human bocavirus in 31.1%, human metapneumovirus in 18.3% and human respiratory syncytial virus in 17.2%. Although increased detection of human enterovirus occurred in summer/autumn months, and there were summer nadirs of human respiratory syncytial virus in both years of the study, there was no obvious viral seasonality in contrast to reports with ARI patients in many regions of the world. CONCLUSION: Respiratory viruses are continuously highly detected during whole year, and without any clinical symptomatology, indicating that viral genome of some virus can persist in lymphoepithelial tissues of the upper respiratory tract.
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spelling pubmed-71128012020-04-02 Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year Proença-Módena, José Luiz Buzatto, Guilherme P. Paula, Flávia E. Saturno, Tamara H. Delcaro, Luana S. Prates, Mirela C. Tamashiro, Edwin Valera, Fabiana C.P. Arruda, Eurico Anselmo-Lima, Wilma T. Int J Pediatr Otorhinolaryngol Article OBJECTIVE: To evaluate the oscillations on the viral detection in adenotonsillar tissues from patients with chronic adenotonsillar diseases as an indicia of the presence of persistent viral infections or acute subclinical infections. STUDY DESIGN: Cross-sectional prospective study. SETTING: Tertiary hospital. METHODS: The fluctuations of respiratory virus detection were compared to the major climatic variables during a two-year period using adenoids and palatine tonsils from 172 children with adenotonsillar hypertrophy and clinical evidence of obstructive sleep apnoea syndrome or recurrent adenotonsillitis, without symptoms of acute respiratory infection (ARI), by TaqMan real-time PCR. RESULTS: The rate of detection of at least one respiratory virus in adenotonsillar tissue was 87%. The most frequently detected viruses were human adenovirus in 52.8%, human enterovirus in 47.2%, human rhinovirus in 33.8%, human bocavirus in 31.1%, human metapneumovirus in 18.3% and human respiratory syncytial virus in 17.2%. Although increased detection of human enterovirus occurred in summer/autumn months, and there were summer nadirs of human respiratory syncytial virus in both years of the study, there was no obvious viral seasonality in contrast to reports with ARI patients in many regions of the world. CONCLUSION: Respiratory viruses are continuously highly detected during whole year, and without any clinical symptomatology, indicating that viral genome of some virus can persist in lymphoepithelial tissues of the upper respiratory tract. Elsevier Ireland Ltd. 2014-10 2014-07-21 /pmc/articles/PMC7112801/ /pubmed/25128448 http://dx.doi.org/10.1016/j.ijporl.2014.07.015 Text en Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Proença-Módena, José Luiz
Buzatto, Guilherme P.
Paula, Flávia E.
Saturno, Tamara H.
Delcaro, Luana S.
Prates, Mirela C.
Tamashiro, Edwin
Valera, Fabiana C.P.
Arruda, Eurico
Anselmo-Lima, Wilma T.
Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year
title Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year
title_full Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year
title_fullStr Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year
title_full_unstemmed Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year
title_short Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year
title_sort respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112801/
https://www.ncbi.nlm.nih.gov/pubmed/25128448
http://dx.doi.org/10.1016/j.ijporl.2014.07.015
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