Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

Mechanical forces are fundamental regulators of cell behaviors. However, molecular regulation of mechanotransduction remain poorly understood. Here, we identified the mechanosensitive channels Piezo1 and Piezo2 as key force sensors required for bone development and osteoblast differentiation. Loss o...

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Detalles Bibliográficos
Autores principales: Zhou, Taifeng, Gao, Bo, Fan, Yi, Liu, Yuchen, Feng, Shuhao, Cong, Qian, Zhang, Xiaolei, Zhou, Yaxing, Yadav, Prem S, Lin, Jiachen, Wu, Nan, Zhao, Liang, Huang, Dongsheng, Zhou, Shuanhu, Su, Peiqiang, Yang, Yingzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112954/
https://www.ncbi.nlm.nih.gov/pubmed/32186512
http://dx.doi.org/10.7554/eLife.52779

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