Cargando…

Urine Steroid Metabolomics as a Novel Tool for Detection of Recurrent Adrenocortical Carcinoma

CONTEXT: Urine steroid metabolomics, combining mass spectrometry-based steroid profiling and machine learning, has been described as a novel diagnostic tool for detection of adrenocortical carcinoma (ACC). OBJECTIVE, DESIGN, SETTING: This proof-of-concept study evaluated the performance of urine ste...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chortis, Vasileios, Bancos, Irina, Nijman, Thomas, Gilligan, Lorna C, Taylor, Angela E, Ronchi, Cristina L, O’Reilly, Michael W, Schreiner, Jochen, Asia, Miriam, Riester, Anna, Perotti, Paola, Libé, Rosella, Quinkler, Marcus, Canu, Letizia, Paiva, Isabel, Bugalho, Maria J, Kastelan, Darko, Dennedy, M Conall, Sherlock, Mark, Ambroziak, Urszula, Vassiliadi, Dimitra, Bertherat, Jerome, Beuschlein, Felix, Fassnacht, Martin, Deeks, Jonathan J, Biehl, Michael, Arlt, Wiebke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Online Only
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112967/ https://www.ncbi.nlm.nih.gov/pubmed/31665449 http://dx.doi.org/10.1210/clinem/dgz141

Ejemplares similares

OR29-2 Mild Autonomous Cortisol Excess (MACE) in Adrenal Incidentalomas - Metabolic Risk Profile and Urinary Steroid Metabolome Analysis in 1208 Prospectively Recruited Patients
por: Prete, Alessandro, et al.
Publicado: (2019)

Results of the ADIUVO Study, the First Randomized Trial on Adjuvant Mitotane in Adrenocortical Carcinoma Patients
por: Terzolo, Massimo, et al.
Publicado: (2021)

Modified GRAS Score for Prognostic Classification of Adrenocortical Carcinoma: An ENSAT Multicentre Study
por: Elhassan, Yasir, et al.
Publicado: (2021)

Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study
por: Bancos, Irina, et al.
Publicado: (2020)

What Is the Optimal Duration of Adjuvant Mitotane Therapy in Adrenocortical Carcinoma? An Unanswered Question
por: Basile, Vittoria, et al.
Publicado: (2021)

S-GRAS score for prognostic classification of adrenocortical carcinoma: an international, multicenter ENSAT study
por: Elhassan, Y S, et al.
Publicado: (2021)

Investigating the Role of Cholesterol and Lipid Trafficking in Mitotane Resistance in Adrenocortical Carcinoma
por: Warde, Kate, et al.
Publicado: (2021)

Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study
por: Terzolo, Massimo, et al.
Publicado: (2023)

Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma
por: Warde, Kate M, et al.
Publicado: (2022)

Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism
por: Arlt, Wiebke, et al.
Publicado: (2017)

THU617 Prolonged Exposure To Target Mitotane Concentrations Is Associated With Better Recurrence-free Survival In Patients With Adrenocortical Carcinoma On Adjuvant Treatment
por: Puglisi, Soraya, et al.
Publicado: (2023)

OR04-5 Circulating Cell-Free DNA-Based Biomarkers For Prognostication and Disease Surveillance in Adrenocortical Carcinoma
por: Altieri, Barbara, et al.
Publicado: (2022)

MANAGEMENT OF ENDOCRINE DISEASE: Imaging for the diagnosis of malignancy in incidentally discovered adrenal masses: a systematic review and meta-analysis
por: Dinnes, Jacqueline, et al.
Publicado: (2016)

Effects of Germline CYP2W1*6 and CYP2B6*6 Single Nucleotide Polymorphisms on Mitotane Treatment in Adrenocortical Carcinoma: A Multicenter ENSAT Study
por: Altieri, Barbara, et al.
Publicado: (2020)

Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality
por: Bancos, Irina, et al.
Publicado: (2017)

Thermal ablation in adrenal disorders: a discussion of the technology, the clinical evidence and the future
por: Donlon, Padraig, et al.
Publicado: (2021)

Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess
por: Chortis, Vasileios, et al.
Publicado: (2018)

SUN-216 Investigating the Role of the Liver X Receptor in Potentiating Mitotane Therapy in Adrenocortical Carcinoma
por: Warde, Kate, et al.
Publicado: (2020)

Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas
por: Weigand, Isabel, et al.
Publicado: (2017)

LBSAT141 Bone Health In Patients With Adrenal Disorders
por: Dogra, Prerna, et al.
Publicado: (2022)

Intratumor heterogeneity of prognostic DNA-based molecular markers in adrenocortical carcinoma
por: Jouinot, Anne, et al.
Publicado: (2020)

Reversal of a Blunted Follicle-Stimulating Hormone by Chemotherapy in an Inhibin B–Secreting Adrenocortical Carcinoma
por: Espiard, Stéphanie, et al.
Publicado: (2017)

RF09 | PSUN05 Increased Frailty in Patients With Functioning Adrenal Adenomas
por: Dogra, Prerna, et al.
Publicado: (2022)

The role of adrenal venous sampling (AVS) in primary bilateral macronodular adrenocortical hyperplasia (PBMAH): a study of 16 patients
por: Rubinstein, German, et al.
Publicado: (2022)

Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma
por: Chortis, Vasileios, et al.
Publicado: (2018)

Adrenocortical carcinoma (ACC): diagnosis, prognosis, and treatment
por: Libé, Rossella
Publicado: (2015)

Evaluation of the Molecular Pathogenesis of Adrenocortical Tumors by Whole-Genome Sequencing
por: Neininger, Kerstin, et al.
Publicado: (2021)

Preoperative Detection of Liver Involvement by Right-Sided Adrenocortical Carcinoma Using CT and MRI
por: Kedra, Alice, et al.
Publicado: (2021)

Laparoscopic or Open Adrenalectomy for Stage I–II Adrenocortical Carcinoma: A Retrospective Study
por: Gaillard, Martin, et al.
Publicado: (2023)

SUN-LB22 PLK1 as a New Treatment Target for Adrenocortical Carcinoma
por: Smith, Gabrielle, et al.
Publicado: (2020)

A Case of Aplasia Cutis Congenita in the Setting of Maternal Carbimazole Use in the First Trimester
por: McGrath, Colin, et al.
Publicado: (2023)

Persisting Muscle Dysfunction in Cushing’s Syndrome Despite Biochemical Remission
por: Vogel, Frederick, et al.
Publicado: (2020)

Transcriptome in paraffin samples for the diagnosis and prognosis of adrenocortical carcinoma
por: Jouinot, Anne, et al.
Publicado: (2022)

Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism
por: Storbeck, Karl-Heinz, et al.
Publicado: (2019)

Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors
por: Arlt, Wiebke, et al.
Publicado: (2011)

Silencing Mutated β-Catenin Inhibits Cell Proliferation and Stimulates Apoptosis in the Adrenocortical Cancer Cell Line H295R
por: Gaujoux, Sébastien, et al.
Publicado: (2013)

Double trouble: two cases of dual adrenal pathologies in one adrenal mass
por: Chortis, Vasileios, et al.
Publicado: (2019)

Inflammation-based scores as predictors of treatment response in advanced adrenocortical carcinoma
por: Mangone, Alessandra, et al.
Publicado: (2023)

Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma
por: Lefèvre, L, et al.
Publicado: (2015)

Hyperthermia as a Steroidogenic Inhibitor of Adrenodortical Cells, an Adrenal Sparing Treatment for Primary Aldosteronism?
por: Donlon, Padraig T, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h8upt49ernp4jdr5takfda53i0