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Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study

PURPOSE: Head and neck squamous cell carcinoma (HNSCC) incidence is high in South America, where recent data on survival are sparse. We investigated the main predictors of HNSCC survival in Brazil, Argentina, Uruguay, and Colombia. METHODS: Sociodemographic and lifestyle information was obtained fro...

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Autores principales: Abrahão, Renata, Perdomo, Sandra, Pinto, Luis Felipe Ribeiro, Nascimento de Carvalho, Flávia, Dias, Fernando Luis, de Podestá, José Roberto V., Ventorin von Zeidler, Sandra, Marinho de Abreu, Priscila, Vilensky, Marta, Giglio, Raul Eduardo, Oliveira, José Carlos, Mineiro, Matinair Siqueira, Kowalski, Luiz P., Ikeda, Mauro K., Cuello, Mauricio, Munyo, Andres, Rodríguez-Urrego, Paula A., Hakim, José Antonio, Suarez-Zamora, David Alfonso, Cayol, Federico, Figari, Marcelo Fernando, Oliver, Javier, Gaborieau, Valerie, Keogh, Ruth H., Brennan, Paul, Curado, Maria Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113075/
https://www.ncbi.nlm.nih.gov/pubmed/32213095
http://dx.doi.org/10.1200/GO.20.00014
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author Abrahão, Renata
Perdomo, Sandra
Pinto, Luis Felipe Ribeiro
Nascimento de Carvalho, Flávia
Dias, Fernando Luis
de Podestá, José Roberto V.
Ventorin von Zeidler, Sandra
Marinho de Abreu, Priscila
Vilensky, Marta
Giglio, Raul Eduardo
Oliveira, José Carlos
Mineiro, Matinair Siqueira
Kowalski, Luiz P.
Ikeda, Mauro K.
Cuello, Mauricio
Munyo, Andres
Rodríguez-Urrego, Paula A.
Hakim, José Antonio
Suarez-Zamora, David Alfonso
Cayol, Federico
Figari, Marcelo Fernando
Oliver, Javier
Gaborieau, Valerie
Keogh, Ruth H.
Brennan, Paul
Curado, Maria Paula
author_facet Abrahão, Renata
Perdomo, Sandra
Pinto, Luis Felipe Ribeiro
Nascimento de Carvalho, Flávia
Dias, Fernando Luis
de Podestá, José Roberto V.
Ventorin von Zeidler, Sandra
Marinho de Abreu, Priscila
Vilensky, Marta
Giglio, Raul Eduardo
Oliveira, José Carlos
Mineiro, Matinair Siqueira
Kowalski, Luiz P.
Ikeda, Mauro K.
Cuello, Mauricio
Munyo, Andres
Rodríguez-Urrego, Paula A.
Hakim, José Antonio
Suarez-Zamora, David Alfonso
Cayol, Federico
Figari, Marcelo Fernando
Oliver, Javier
Gaborieau, Valerie
Keogh, Ruth H.
Brennan, Paul
Curado, Maria Paula
author_sort Abrahão, Renata
collection PubMed
description PURPOSE: Head and neck squamous cell carcinoma (HNSCC) incidence is high in South America, where recent data on survival are sparse. We investigated the main predictors of HNSCC survival in Brazil, Argentina, Uruguay, and Colombia. METHODS: Sociodemographic and lifestyle information was obtained from standardized interviews, and clinicopathologic data were extracted from medical records and pathologic reports. The Kaplan-Meier method and Cox regression were used for statistical analyses. RESULTS: Of 1,463 patients, 378 had a larynx cancer (LC), 78 hypopharynx cancer (HC), 599 oral cavity cancer (OC), and 408 oropharynx cancer (OPC). Most patients (55.5%) were diagnosed with stage IV disease, ranging from 47.6% for LC to 70.8% for OPC. Three-year survival rates were 56.0% for LC, 54.7% for OC, 48.0% for OPC, and 37.8% for HC. In multivariable models, patients with stage IV disease had approximately 7.6 (LC/HC), 11.7 (OC), and 3.5 (OPC) times higher mortality than patients with stage I disease. Current and former drinkers with LC or HC had approximately 2 times higher mortality than never-drinkers. In addition, older age at diagnosis was independently associated with worse survival for all sites. In a subset analysis of 198 patients with OPC with available human papillomavirus (HPV) type 16 data, those with HPV-unrelated OPC had a significantly worse 3-year survival compared with those with HPV-related OPC (44.6% v 75.6%, respectively), corresponding to a 3.4 times higher mortality. CONCLUSION: Late stage at diagnosis was the strongest predictor of lower HNSCC survival. Early cancer detection and reduction of harmful alcohol use are fundamental to decrease the high burden of HNSCC in South America.
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spelling pubmed-71130752020-04-02 Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study Abrahão, Renata Perdomo, Sandra Pinto, Luis Felipe Ribeiro Nascimento de Carvalho, Flávia Dias, Fernando Luis de Podestá, José Roberto V. Ventorin von Zeidler, Sandra Marinho de Abreu, Priscila Vilensky, Marta Giglio, Raul Eduardo Oliveira, José Carlos Mineiro, Matinair Siqueira Kowalski, Luiz P. Ikeda, Mauro K. Cuello, Mauricio Munyo, Andres Rodríguez-Urrego, Paula A. Hakim, José Antonio Suarez-Zamora, David Alfonso Cayol, Federico Figari, Marcelo Fernando Oliver, Javier Gaborieau, Valerie Keogh, Ruth H. Brennan, Paul Curado, Maria Paula JCO Glob Oncol Original Reports PURPOSE: Head and neck squamous cell carcinoma (HNSCC) incidence is high in South America, where recent data on survival are sparse. We investigated the main predictors of HNSCC survival in Brazil, Argentina, Uruguay, and Colombia. METHODS: Sociodemographic and lifestyle information was obtained from standardized interviews, and clinicopathologic data were extracted from medical records and pathologic reports. The Kaplan-Meier method and Cox regression were used for statistical analyses. RESULTS: Of 1,463 patients, 378 had a larynx cancer (LC), 78 hypopharynx cancer (HC), 599 oral cavity cancer (OC), and 408 oropharynx cancer (OPC). Most patients (55.5%) were diagnosed with stage IV disease, ranging from 47.6% for LC to 70.8% for OPC. Three-year survival rates were 56.0% for LC, 54.7% for OC, 48.0% for OPC, and 37.8% for HC. In multivariable models, patients with stage IV disease had approximately 7.6 (LC/HC), 11.7 (OC), and 3.5 (OPC) times higher mortality than patients with stage I disease. Current and former drinkers with LC or HC had approximately 2 times higher mortality than never-drinkers. In addition, older age at diagnosis was independently associated with worse survival for all sites. In a subset analysis of 198 patients with OPC with available human papillomavirus (HPV) type 16 data, those with HPV-unrelated OPC had a significantly worse 3-year survival compared with those with HPV-related OPC (44.6% v 75.6%, respectively), corresponding to a 3.4 times higher mortality. CONCLUSION: Late stage at diagnosis was the strongest predictor of lower HNSCC survival. Early cancer detection and reduction of harmful alcohol use are fundamental to decrease the high burden of HNSCC in South America. American Society of Clinical Oncology 2020-03-26 /pmc/articles/PMC7113075/ /pubmed/32213095 http://dx.doi.org/10.1200/GO.20.00014 Text en © 2020 by American Society of Clinical Oncology https://creativecommons.org/licenses/by-nc-nd/4.0/ Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original Reports
Abrahão, Renata
Perdomo, Sandra
Pinto, Luis Felipe Ribeiro
Nascimento de Carvalho, Flávia
Dias, Fernando Luis
de Podestá, José Roberto V.
Ventorin von Zeidler, Sandra
Marinho de Abreu, Priscila
Vilensky, Marta
Giglio, Raul Eduardo
Oliveira, José Carlos
Mineiro, Matinair Siqueira
Kowalski, Luiz P.
Ikeda, Mauro K.
Cuello, Mauricio
Munyo, Andres
Rodríguez-Urrego, Paula A.
Hakim, José Antonio
Suarez-Zamora, David Alfonso
Cayol, Federico
Figari, Marcelo Fernando
Oliver, Javier
Gaborieau, Valerie
Keogh, Ruth H.
Brennan, Paul
Curado, Maria Paula
Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study
title Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study
title_full Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study
title_fullStr Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study
title_full_unstemmed Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study
title_short Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study
title_sort predictors of survival after head and neck squamous cell carcinoma in south america: the interchange study
topic Original Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113075/
https://www.ncbi.nlm.nih.gov/pubmed/32213095
http://dx.doi.org/10.1200/GO.20.00014
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