Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes

PURPOSE OF REVIEW: Type 1 and type 2 diabetes are often accompanied by mostly mild forms of exocrine pancreatic insufficiency. Despite high prevalence, little is known about the clinical consequences of exocrine pancreatic insufficiency and its optimal (nutritional) treatment. Even less is known if...

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Detalles Bibliográficos
Autores principales: Radlinger, Bernhard, Ramoser, Gabriele, Kaser, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Other Forms of Diabetes and Its Complications (JJ Nolan and H Thabit, Section Editors)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113197/
https://www.ncbi.nlm.nih.gov/pubmed/32239341
http://dx.doi.org/10.1007/s11892-020-01304-0
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author Radlinger, Bernhard
Ramoser, Gabriele
Kaser, Susanne
author_facet Radlinger, Bernhard
Ramoser, Gabriele
Kaser, Susanne
author_sort Radlinger, Bernhard
collection PubMed
description PURPOSE OF REVIEW: Type 1 and type 2 diabetes are often accompanied by mostly mild forms of exocrine pancreatic insufficiency. Despite high prevalence, little is known about the clinical consequences of exocrine pancreatic insufficiency and its optimal (nutritional) treatment. Even less is known if and to what extent exocrine pancreas insufficiency also affects glycemic control in diabetes. This article aims for summarizing current clinical knowledge on screening, diagnosis, and treatment and gives an overview on the pathophysiology of exocrine pancreatic insufficiency in diabetes. RECENT FINDINGS: Recent studies reveal novel insights into the close interaction of acinar, ductal, and endocrine cells and the gut-pancreas axis. SUMMARY: Exocrine pancreatic insufficiency is a clinically relevant, frequent but poorly understood disorder in both type 1 and type 2 diabetes.
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spelling pubmed-71131972020-04-06 Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes Radlinger, Bernhard Ramoser, Gabriele Kaser, Susanne Curr Diab Rep Other Forms of Diabetes and Its Complications (JJ Nolan and H Thabit, Section Editors) PURPOSE OF REVIEW: Type 1 and type 2 diabetes are often accompanied by mostly mild forms of exocrine pancreatic insufficiency. Despite high prevalence, little is known about the clinical consequences of exocrine pancreatic insufficiency and its optimal (nutritional) treatment. Even less is known if and to what extent exocrine pancreas insufficiency also affects glycemic control in diabetes. This article aims for summarizing current clinical knowledge on screening, diagnosis, and treatment and gives an overview on the pathophysiology of exocrine pancreatic insufficiency in diabetes. RECENT FINDINGS: Recent studies reveal novel insights into the close interaction of acinar, ductal, and endocrine cells and the gut-pancreas axis. SUMMARY: Exocrine pancreatic insufficiency is a clinically relevant, frequent but poorly understood disorder in both type 1 and type 2 diabetes. Springer US 2020-04-01 2020 /pmc/articles/PMC7113197/ /pubmed/32239341 http://dx.doi.org/10.1007/s11892-020-01304-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Other Forms of Diabetes and Its Complications (JJ Nolan and H Thabit, Section Editors)
Radlinger, Bernhard
Ramoser, Gabriele
Kaser, Susanne
Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes
title Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes
title_full Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes
title_fullStr Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes
title_full_unstemmed Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes
title_short Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes
title_sort exocrine pancreatic insufficiency in type 1 and type 2 diabetes
topic Other Forms of Diabetes and Its Complications (JJ Nolan and H Thabit, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113197/
https://www.ncbi.nlm.nih.gov/pubmed/32239341
http://dx.doi.org/10.1007/s11892-020-01304-0
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