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Pretreatment Tumor DNA Sequencing of KIT and PDGFRA in Endosonography-Guided Biopsies Optimizes the Preoperative Management of Gastrointestinal Stromal Tumors

BACKGROUND: Neoadjuvant tyrosine kinase inhibitor (TKI) therapy increases the chance of organ-preserving, radical resection in selected patients with gastrointestinal stromal tumors (GISTs). We aimed to evaluate systematic, immediate DNA sequencing of KIT and PDGFRA in pretreatment GIST tissue to gu...

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Detalles Bibliográficos
Autores principales:	Hedenström, Per, Andersson, Carola, Sjövall, Henrik, Enlund, Fredrik, Nilsson, Ola, Nilsson, Bengt, Sadik, Riadh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113213/ https://www.ncbi.nlm.nih.gov/pubmed/32124386 http://dx.doi.org/10.1007/s40291-020-00451-0

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