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Linagliptin affects IRS1/Akt signaling and prevents high glucose-induced apoptosis in podocytes

Diabetes-induced podocyte apoptosis is considered to play a critical role in the pathogenesis of diabetic kidney disease (DKD). We proposed that hyperglycaemia can induce podocyte apoptosis by inhibiting the action of podocyte survival factors, thus inactivating the cellular effects of insulin signa...

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Detalles Bibliográficos
Autores principales:	Mima, Akira, Yasuzawa, Toshinori, Nakamura, Tomomi, Ueshima, Shigeru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113296/ https://www.ncbi.nlm.nih.gov/pubmed/32238837 http://dx.doi.org/10.1038/s41598-020-62579-7

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