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Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells

BACKGROUND: Chronic inflammatory conditions like obesity may adversely impact the biological functions underlying the regenerative potential of mesenchymal stromal/stem cells (MSC). Obesity can impair MSC function by inducing cellular senescence, a growth-arrest program that transitions cells to a p...

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Detalles Bibliográficos
Autores principales:	Conley, Sabena M., Hickson, LaTonya J., Kellogg, Todd A., McKenzie, Travis, Heimbach, Julie K., Taner, Timucin, Tang, Hui, Jordan, Kyra L., Saadiq, Ishran M., Woollard, John R., Isik, Busra, Afarideh, Mohsen, Tchkonia, Tamar, Kirkland, James L., Lerman, Lilach O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113401/ https://www.ncbi.nlm.nih.gov/pubmed/32274385 http://dx.doi.org/10.3389/fcell.2020.00197

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