Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor

Diabetic cardiomyopathy (DCM) is a severe complication of type 1 diabetic (T1D) patients, manifested as combined diastolic and systolic dysfunction. DCM is associated with impaired calcium homeostasis secondary to decreased calcium-sensitive receptor (CaSR) expression. Spermine, a direct agonist of...

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Detalles Bibliográficos
Autores principales: Wang, Yuehong, Chen, Junting, Li, Siwei, Zhang, Xinying, Guo, Zuoming, Hu, Jing, Shao, Xiaoting, Song, Ningyang, Zhao, Yajun, Li, Hongzhu, Yang, Guangdong, Xu, Changqing, Wei, Can
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113441/
https://www.ncbi.nlm.nih.gov/pubmed/32234613
http://dx.doi.org/10.1016/j.redox.2020.101514

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