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Comparative Molecular Dynamics Simulations Provide Insight Into Antibiotic Interactions: A Case Study Using the Enzyme L,L-Diaminopimelate Aminotransferase (DapL)

The L,L-diaminopimelate aminotransferase (DapL) pathway, a recently discovered variant of the lysine biosynthetic pathway, is an attractive pipeline to identify targets for the development of novel antibiotic compounds. DapL is a homodimer that catalyzes the conversion of tetrahydrodipicolinate to L...

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Detalles Bibliográficos
Autores principales:	Adams, Lily E., Rynkiewicz, Patrick, Babbitt, Gregory A., Mortensen, Jamie S., North, Rachel A., Dobson, Renwick C. J., Hudson, André O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113581/ https://www.ncbi.nlm.nih.gov/pubmed/32274387 http://dx.doi.org/10.3389/fmolb.2020.00046

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