Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles

Replication of eukaryotic positive-stranded RNA viruses is usually linked to the presence of membrane-associated replicative organelles. The purpose of this review is to discuss the function of proteins responsible for formation of the coronavirus replicative organelle. This will be done by identify...

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Detalles Bibliográficos
Autor principal: Neuman, Benjamin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113682/
https://www.ncbi.nlm.nih.gov/pubmed/27743916
http://dx.doi.org/10.1016/j.antiviral.2016.10.005
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author Neuman, Benjamin W.
author_facet Neuman, Benjamin W.
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description Replication of eukaryotic positive-stranded RNA viruses is usually linked to the presence of membrane-associated replicative organelles. The purpose of this review is to discuss the function of proteins responsible for formation of the coronavirus replicative organelle. This will be done by identifying domains that are conserved across the order Nidovirales, and by summarizing what is known about function and structure at the level of protein domains.
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spelling pubmed-71136822020-04-02 Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles Neuman, Benjamin W. Antiviral Res Article Replication of eukaryotic positive-stranded RNA viruses is usually linked to the presence of membrane-associated replicative organelles. The purpose of this review is to discuss the function of proteins responsible for formation of the coronavirus replicative organelle. This will be done by identifying domains that are conserved across the order Nidovirales, and by summarizing what is known about function and structure at the level of protein domains. Elsevier B.V. 2016-11 2016-10-13 /pmc/articles/PMC7113682/ /pubmed/27743916 http://dx.doi.org/10.1016/j.antiviral.2016.10.005 Text en © 2016 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Neuman, Benjamin W.
Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles
title Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles
title_full Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles
title_fullStr Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles
title_full_unstemmed Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles
title_short Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles
title_sort bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113682/
https://www.ncbi.nlm.nih.gov/pubmed/27743916
http://dx.doi.org/10.1016/j.antiviral.2016.10.005
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