Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases

Proteolytical cleavage of the picornaviral polyprotein is essential for viral replication. Therefore, viral proteases are attractive targets for anti-viral therapy. Most assays available for testing proteolytical activity of proteases are performed in vitro, using heterologously expressed proteases...

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Detalles Bibliográficos
Autores principales: van der Linden, Lonneke, Ulferts, Rachel, Nabuurs, Sander B., Kusov, Yuri, Liu, Hong, George, Shyla, Lacroix, Céline, Goris, Nesya, Lefebvre, David, Lanke, Kjerstin H.W., De Clercq, Kris, Hilgenfeld, Rolf, Neyts, Johan, van Kuppeveld, Frank J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113757/
https://www.ncbi.nlm.nih.gov/pubmed/24393668
http://dx.doi.org/10.1016/j.antiviral.2013.12.012

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