Protection from pulmonary tissue damage associated with infection of cynomolgus macaques by highly pathogenic avian influenza virus (H5N1) by low dose natural human IFN-α administered to the buccal mucosa

Using an established nonhuman primate model for H5N1 highly pathogenic influenza virus infection in humans, we have been able to demonstrate the prophylactic mitigation of the pulmonary damage characteristic of human fatal cases from primary influenza virus pneumonia with a low dose oral formulation...

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Detalles Bibliográficos
Autores principales: Strayer, David R., Carter, William A., Stouch, Bruce C., Stittelaar, Koert J., Thoolen, Robert J.M.M., Osterhaus, Albert D.M.E., Mitchell, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113766/
https://www.ncbi.nlm.nih.gov/pubmed/25111905
http://dx.doi.org/10.1016/j.antiviral.2014.07.010

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